Method of the Year 2009
-
Proteomics
-
46+ votes
23- votes
- Log in to vote
-
Direct observation of individual endogenous protein complexes in situ by proximity ligation
- Ola Söderberg, Mats Gullberg, Malin Jarvius, Karin Ridderstråle, Karl-Johan Leuchowius, Jonas Jarvius, Kenneth Wester, Per Hydbring, Fuad Bahram, Lars-Gunnar Larsson, Ulf Landegren,
- Original article citation: Nat Meth 3," 995 - 1000, (2006).
- Categories: Proteomics, Biotechnology, Cell biology, and Imaging
- Recommended by: Olle Ericsson on 09/15/2008 02:56PM GMT
- Reasons for recommending:
In situ PLA for the first time enables researchers to analyze protein protein interaction in untampered samples like for example clinical material.Furthermore the technique identifies the exact subcellular localization where the interaction occurs. The utilization of the method is spreading rapidly in the research community and provide scientists with unique important functional information of cellular functions which so far has been unavailable.
-
Comments
Reader comments are usually moderated after posting. For more controversial topics, we reserve the right to moderate before comments are published.
Add your own comment
You can be as critical or controversial as you like, but please don't get personal or offensive, and do keep it brief. Remember this is for feedback and discussion - not for publishing papers, press releases or advertisements, for example.
You need to be registered with Nature to leave a comment. Please log in or register as a new user. You will be re-directed back to this page.
