Method of the Year 2009
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Systems biology
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11+ votes
6- votes
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The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition
- Original article citation: Genome Biol 9," R127 , (2008).
- Categories: Systems biology and Genetics and genomics
- Recommended by: Amanda Zhou on 10/31/2008 09:01AM GMT
- Reasons for recommending:
In this paper the authors describe a systems biology method for detecting the biological function of microRNAs that does not require a priori knowledge of biologically validated gene targets - previously a bottleneck to studying the function of miRNAs. Nature Methods has previously highlighted the need for high-throughput target validation in part because of this bottleneck, demonstrating the importance of this approach.
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