Method of the Year 2009
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Cell biology
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22+ votes
12- votes
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Watching single molecules in cells
- Original article citation: Nat Meth 5," 25 - 25, (2008).
- Categories: Cell biology, Imaging, and Others
- Recommended by: Daniel Evanko on 07/23/2009 09:10PM GMT
- Reasons for recommending:
In vivo measurement of single molecules is a very challenging area technically. But the enormity of the rewards at stake made us highlight, back in 2007, this area of research as one to watch. The level of progress in 2008 was incremental but developments seem to be gradually improving and there is no question that some landmark papers have been published. Has the progress been sufficient?
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Most of bio-active compounds into cell( like Actinomycetes) are present as single molecule which need to be identified,isolated & evaluated for it's bioefficacy.Still not much progress has been made in this area.We used to study DNA sequences variation for molecular diversity study but each & every molecule need to be taken in account.These biomolecules are of immense potential.Hence i recommend method to watch single molecule in the cell as METHOD of the year 2009. Anurag chaurasia,ICAR, India, anurag@nbaim.org anurag_vns1@yahoo.co.in +919452196686 (M)