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• Peptide Microarrays is a revolutionary technology, in the sense that, traditionally scientists used radio-labeling followed by mutagenesis to find out the phosphorylation sites on a given protein. With the advent of mass spectrometry, 1000's of phosphorylation sites have been identified. Peptide microarrays is a novel platform that allows high throughput identification and assignment of phosphorylation sites on a given protein. This technology can be used to probe cancer and cell signaling pathways, where a number of phosphorylation sites have been known from literature. Traditionally, degenerate peptide libraries have been used to build artificial motifs for kinases but using peptide microarrays, one can not only assign motifs for a kinase, but also identify the real kinase substrates in a specific signaling pathway.

  • Aug 24, 2009
  • Posted by: Ramars Amanchy

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