Method of the Year 2009
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Proteomics
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2+ votes
9- votes
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Universal sample preparation method for proteome analysis
- Original article citation: Nat Meth 6," 359 - 362, (2009).
- Categories: Proteomics, Biotechnology, Protein biochemistry, and Systems biology
- Recommended by: Peter Nollert on 08/24/2009 11:54PM GMT
- Reasons for recommending:
1. the filter-aided sample preparation method impacts the 'forgotten half' of proteomics: membrane proteins & their complexes 2. the method described is *very* simple: SDS & urea reagent and a MWCO filter; no new tools required at all
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This article describes a more thorough investigation of an already published method by Manza et al. in 2005 (Manza LL, Stamer SL, Ham AJ, Codreanu SG, Liebler DC. Proteomics. 2005 May;5(7):1742-5.). Therefore, in my opinion, the Liebler lab should be credited for this very useful, but not particularly new, method.