Method of the Year 2009
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Cell biology
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9+ votes
6- votes
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Global identification of yeast chromosome interactions using Genome conformation capture
- Original article citation: Fungal Genetics and Biology 46," 879 - 886, (2009).
- Categories: Cell biology, Biotechnology, Genetics and genomics, and Systems biology
- Recommended by: Cliff Dawson on 10/23/2009 01:06AM GMT
- Reasons for recommending:
Genome conformation capture (GCC) is a powerful method to uncover inter- and intra- chromosomal interactions that underlie genome architecture, in any cell, under any condition. This method utilises next-generation sequencing, and is the first described method of its type, with the Hi-C (Lieberman-Aiden et al) method following shortly after. Analyses reveal exciting prospects for cell biology.
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