Method of the Year 2009
In 2007 we chose Next Generation Sequencing.
In 2008 we chose Super-resolution Imaging.
Now it is time for you, our readers, to help us choose the Method of the Year 2009. Just sign in using your free nature.com registration and vote on our Methods to Watch from previous years or a paper that a visitor has recommended.
Alternatively, you can recommend a paper that represents a method you believe came into its own in 2009 and will have a wide-ranging impact on biology. This paper can be any recently published paper from this year or past years published in any journal. Just provide a link to the paper or other online description of the method and vote away!
Want more information or want to comment? Read the editorial or go to our blog methagora and comment.
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9 votes
Protein biochemistry
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4+ votes
5- votes
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Structural analysis of macromolecular assemblies
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Original article citation: Nat Meth 5," 23 - 23, (2008). - Categories: Protein biochemistry, Cell biology, Imaging, and Proteomics
- Recommended by the Editor: Allison Doerr on 07/27/2009 01:56PM GMT
In the 2007 Methods to Watch, Nature Methods highlighted how researchers have begun to integrate proteomics techniques, cryo-electron microscopy, X-ray crystallography, NMR spectroscopy and computational tools to tackle the structure of large macromolecular assemblies like the nuclear pore complex. What do you think of the progress in this area since? - Comment on this subject: 1 comment made
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6 votes
Proteomics
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2+ votes
4- votes
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Peptide Microarrays
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Original article citation: Journal of Proteome research 7," 3900 - 3910, (2008). - Categories: Proteomics, Biotechnology, Protein biochemistry, and Chemical biology
- Recommended by : Ramars Amanchy on 08/24/2009 09:09PM GMT
1. Peptide microarrays is a new technology with tremendous potential 2. Tremendous impact 3. Multitude of applications 4. Complements tradional kinase motif finding algorithms and techniques. 5. cancer/Kinase profiling - Comment on this subject: 1 comment made
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7 votes
Synthetic biology
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2+ votes
5- votes
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Synthetic life
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Original article citation: Nat Meth 6," 33 - 33, (2009). - Categories: Synthetic biology and Microbiology
- Recommended by the Editor: Nicole Rusk on 07/23/2009 11:01PM GMT
2008 saw the first in vitro reconstruction of an entire bacterial synthetic genome. Will others follow and will they prove to be functional? - Comment on this subject: 0 comments made
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11 votes
Proteomics
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2+ votes
9- votes
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Universal sample preparation method for proteome analysis
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Original article citation: Nat Meth 6," 359 - 362, (2009). - Categories: Proteomics, Biotechnology, Protein biochemistry, and Systems biology
- Recommended by : Peter Nollert on 08/24/2009 11:54PM GMT
1. the filter-aided sample preparation method impacts the 'forgotten half' of proteomics: membrane proteins & their complexes 2. the method described is *very* simple: SDS & urea reagent and a MWCO filter; no new tools required at all - Comment on this subject: 1 comment made
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13 votes
Cell biology
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1+ votes
12- votes
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Experimental micro-matchmaking
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Original article citation: Nat Meth 6," 36 - 36, (2009). - Categories: Cell biology, Genetics and genomics, and Systems biology
- Recommended by the Editor: Nicole Rusk on 07/28/2009 04:24PM GMT
How close are we to a reliable high-throughput experimental validation for computationally predicted microRNA targets? - Comment on this subject: 0 comments made
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13 votes
Systems biology
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1+ votes
12- votes
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A meta-network of -omics
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Original article citation: Nat Meth 5," 25 - 25, (2008). - Categories: Systems biology, Genetics and genomics, Cell biology, and Proteomics
- Recommended by the Editor: Nicole Rusk on 07/28/2009 04:36PM GMT
In 2007 we called for a network that would link databases in the biosciences in our Methods to Watch section. We envisaged a scenario in which a wealth of information on, for example, genome, epigenome, transcriptome, proteome, and glycome would be easily accessible to a researcher and aid in the scientific discovery process. Is there still a need for such a meta-network or are scientists satisfied with the current network of databases? - Comment on this subject: 0 comments made
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