Method of the Year 2009
In 2007 we chose Next Generation Sequencing.
In 2008 we chose Super-resolution Imaging.
Now it is time for you, our readers, to help us choose the Method of the Year 2009. Just sign in using your free nature.com registration and vote on our Methods to Watch from previous years or a paper that a visitor has recommended.
Alternatively, you can recommend a paper that represents a method you believe came into its own in 2009 and will have a wide-ranging impact on biology. This paper can be any recently published paper from this year or past years published in any journal. Just provide a link to the paper or other online description of the method and vote away!
Want more information or want to comment? Read the editorial or go to our blog methagora and comment.
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Genetics and genomics
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21+ votes
2- votes
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Full Dynamic Range Proteome Analysis of S. cerevisiae by Targeted Proteomics
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Original article citation: Cell 138," 795 - 806, (2009). - Categories: Proteomics, Genetics and genomics, and Systems biology
- Recommended by : Herman Altenried on 11/05/2009 02:42AM GMT
The publication shows that by using MRM based targeted proteomics an unsurpassed sensitivity, reproducibility and throughput in proteomics experiments is achieved. This is the first glimpse into the future of proteomics!! - Comment on this subject: 0 comments made
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2+ votes
0- votes
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Direct RNA sequencing
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Original article citation: Nature 461," 814 - 818, (2009). - Categories: Others, Genetics and genomics, Cell biology, and Synthetic biology
- Recommended by : Bekir Ulker on 11/03/2009 06:10PM GMT
Direct RNA sequencing without converting RNA to cDNA, a long desired method now on the edge of being readily available to scientists. This method eliminates the biases, complexity and errors introduced by nucleic acid amplification and requires minute amounts of starting RNA material. This method would lead to major surprises and discoveries in RNA processing as well as various RNA species that organisms might have and the biological roles. - Comment on this subject: 0 comments made
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9+ votes
6- votes
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Global identification of yeast chromosome interactions using Genome conformation capture
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Original article citation: Fungal Genetics and Biology 46," 879 - 886, (2009). - Categories: Cell biology, Biotechnology, Genetics and genomics, and Systems biology
- Recommended by : Cliff Dawson on 10/23/2009 01:06AM GMT
Genome conformation capture (GCC) is a powerful method to uncover inter- and intra- chromosomal interactions that underlie genome architecture, in any cell, under any condition. This method utilises next-generation sequencing, and is the first described method of its type, with the Hi-C (Lieberman-Aiden et al) method following shortly after. Analyses reveal exciting prospects for cell biology. - Comment on this subject: 0 comments made
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20+ votes
10- votes
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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
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Original article citation: Science 326," 289 - 293, (2009). - Categories: Cell biology and Genetics and genomics
- Recommended by : David Galas on 10/21/2009 03:43PM GMT
The added power of this modified method to lay out the 3D arrangement of the chromosomes of the genome in the nucleus is a major advance. we had some information before this, but now we can look at the full arrangement, in any cells, underany conditions. Very clever technique coupled with beautiful computational analysis. - Comment on this subject: 0 comments made
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12+ votes
7- votes
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A 3D digital atlas of C. elegans and its application to single-cell analyses
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Original article citation: Nat Meth 6," 667 - 672, (2009). - Categories: Biotechnology, Genetics and genomics, Systems biology, and Cell biology
- Recommended by : Hanchuan Peng on 09/09/2009 02:45AM GMT
Isn't it a cool thing to be able to target individual cells uniquely and unambiguously? - Comment on this subject: 2 comments made
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3+ votes
3- votes
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The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing
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Original article citation: Science 320," 1344 - 1349, (2008). - Categories: Genetics and genomics and Cell biology
- Recommended by the Editor: Nicole Rusk on 08/14/2009 12:23AM GMT
Though followed within a few weeks by independent groups from the Sanger institute, Cal Tech and University of Queensland this was the first paper describing RNA-seq and thus the first to show the power of second generation sequencing for transcriptome analysis. - Comment on this subject: 0 comments made
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1+ votes
12- votes
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A meta-network of -omics
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Original article citation: Nat Meth 5," 25 - 25, (2008). - Categories: Systems biology, Genetics and genomics, Cell biology, and Proteomics
- Recommended by the Editor: Nicole Rusk on 07/28/2009 04:36PM GMT
In 2007 we called for a network that would link databases in the biosciences in our Methods to Watch section. We envisaged a scenario in which a wealth of information on, for example, genome, epigenome, transcriptome, proteome, and glycome would be easily accessible to a researcher and aid in the scientific discovery process. Is there still a need for such a meta-network or are scientists satisfied with the current network of databases? - Comment on this subject: 0 comments made
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1+ votes
12- votes
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Experimental micro-matchmaking
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Original article citation: Nat Meth 6," 36 - 36, (2009). - Categories: Cell biology, Genetics and genomics, and Systems biology
- Recommended by the Editor: Nicole Rusk on 07/28/2009 04:24PM GMT
How close are we to a reliable high-throughput experimental validation for computationally predicted microRNA targets? - Comment on this subject: 0 comments made
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