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Reversible Surface Switching of Nanogel Triggered by External Stimuli
- Xiaochen Shen, Leyang Zhang, Xiqun Jiang, Yong Hu, Jian Guo,
- Original article citation: Angew. Chem. Int. Ed. 46," 7104 - 7107, (2007).
- Categories: Chemistry and Materials
- Recommended by: Gemma Moxham on 11/21/2007 11:38AM GMT
- Reasons for recommending:
Many organisms are able to change the properties of their surface membrane proteins in response to a change in pH in order to overcome biological membrane barriers. It is highly desirable to mimic such behaviour synthetically for biomedical and pharmaceutical application, hence, a variety of stimuli-responsive polymeric systems have been developed. However, the alterations that occur on a change in pH usually involve a disassembly process result in a change in dimension. In this papar the preparation of a novel nanogel of two biocompatible components is described which has a fully reversible pH-dependent switch process. The particle integrity is maintained over the entire pH range and the nanogel structure better resembles the structures of most organisms than the usual block co-polymer assemblies.
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