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Highly Efficient Au(I)-Catalyzed Intramolecular Addition of β-Ketoamide to Unactivated Alkenes
- C.-Y. Zhou, C.-M. Che,
- Original article citation: J. Am. Chem. Soc. 129," 5828 - 5829, (2007).
- Categories: Chemistry
- Recommended by: Gemma Moxham on 12/06/2007 04:12PM GMT
- Reasons for recommending:
The addition of C-H bonds across a C=C double bond is a valuable method of C-C bond formation. It has been shown that Au(I) and Au(III) complexes can catalyse addition of a beta-ketone to an alkene but only for electron rich alkenes. In this paper, Au(I) catalysts are shown to catalyse the addition of a beta-ketoamide to unactivated alkenes to aford highly substituted lactams with excellent yields and regioselectivities under mild reaction conditions.
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