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Cell & Molecular Biology
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Bid is not required for Bax translocation during UV-induced apoptosis
- Y WU, D XING, W CHEN, X WANG,
- Original article citation: Cellular Signalling 19," 2468 - 2478, (2007).
- Categories: Cell & Molecular Biology
- Recommended by: Mike X. Chen on 01/14/2008 09:19PM GMT
- Reasons for recommending:
Multiple signaling pathways are involved in UV-induced apoptosis, among which Bax activation has been proposed as an important factor. However, the regulation of Bax activation remains elusive. In this paper, Wu et al employed FRET (fluorescence resonance energy transfer) technique to visualize the real-time intracellular events at a single-cell level. A novel mechanism has been revealed that Bax activation is a Bid-independent event in UV irradiation-induced apoptosis.
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