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Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study
- Kun Wang, Meng Liang, Liang Wang, Lixia Tian, Xinqing Zhang, Kuncheng Li, Tianzi Jiang,
- Original article citation: Hum. Brain Mapp. 28," 967 - 978, (2007).
- Categories: Neuroscience
- Recommended by: Yong HE on 02/18/2008 12:26PM GMT
- Reasons for recommending:
Alzheimer’s disease (AD) is the most common type of dementia associated with aging. To explore AD-related alteration in the brain functionality, Wang et al. employed resting-state functional MRI to investigate inter-regional correlations of spontaneous brain activity. They found that, compared with the controls, AD patients had decreased positive correlations between the prefrontal and parietal regions, and increased positive correlations within the prefrontal, parietal and occipital regions. In addition, they also found that AD patients had decreased negative correlations between two intrinsically anti-correlated networks that had been exhibited to be intrinsically organized in the healthy brain. This study provides important evidence for abnormal functional integrity among regions in AD.
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