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Auditory fear conditioning modulates prepulse inhibition in socially reared rats and isolation-reared rats.
- Nanxin Li, Junli Ping, Rongbin Wu, Chao Wang, Xihong Wu, Liang Li,
- Original article citation: Behavioral Neuroscience 122," 107 - 118, (2008).
- Categories: Neuroscience
- Recommended by: Chun Wang on 07/30/2008 08:05PM GMT
- Reasons for recommending:
This fascinating study for the first time shows that isolation rearing could not only impair prepulse inhibition, a commonly used sensorimotor gating model of schizophrenia, but also significantly impair the attentional modulation of prepulse inhibition. The authors further demonstrate that this effect is modulated via metabolic glutamate receptors. This work provides a brand new animal model for investigating both neural bases and cognitive features of schizophrenia.
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