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Developmental Biology
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Surviving Endoplasmic Reticulum Stress Is Coupled to Altered Chondrocyte Differentiation and Function
- Kwok Yeung Tsang, Danny Chan, Deborah Cheslett, Wilson C. W. Chan, Chi Leong So, Ian G. Melhado, Tori W. Y. Chan, Kin Ming Kwan, Ernst B. Hunziker, Yoshihiko Yamada, John F. Bateman, Kenneth M. C. Cheung, Kathryn S. E. Cheah,
- Original article citation: Plos Biol 5," (2007).
- Categories: Developmental Biology, Genetics, Cell & Molecular Biology, and Clinical Medicine
- Recommended by: Dong-Yan Jin on 04/20/2007 03:32AM GMT
- Reasons for recommending:
In this study, a transgenic mouse model with 13bp deletion in Col10a1 (13del) was made and characterized. The same mutation has been found in human patients with Schmid metaphyseal chondrodysplasia (SMCD). This work has substantially advanced our understanding of 13del as well as its pathological roles in SMCD. It also creates a valuable mouse model for studying cartilage and bone development. The observations made on expansion of hypertrophic zone and its correlation with activation of ER stress significantly open up the field and provide new avenues for future studies.
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