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User-recommended papers allows you to suggest a paper you would like to see on Nature China. When these papers appear on our site, users may comment and vote on them. To recommend a paper please use this form. Please note that you cannot recommend a paper you have authored. The editors will reject any self-recommendations. All comments and recommendation are checked by the editors and may be edited prior to publication on the site.

• Cell & Molecular Biology

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  • A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii

    • T. Zhao, G. Li, S. Mi, S. Li, G. J. Hannon, X.-J. Wang, Y. Qi
      Original article citation: Genes & Development 21," 1190 - 1203, (2007).

    • Categories: Cell & Molecular Biology
    • Recommended by : Xinran Li on 11/19/2007 02:22AM GMT
      
      This article presents the first discovery of microRNAs in a unicellular organism, while the miRNAs which have been identified before only exist in multicellular organisms. This discovery also has evolutionary implications, suggesting the miRNA genes in algae, plants and animals might evolved independently.
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  • Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray

    • H. He, J. Wang, T. Liu, X. S. Liu, T. Li, Y. Wang, Z. Qian, H. Zheng, X. Zhu, T. Wu, B. Shi, W. Deng, W. Zhou, G. Skogerbo, R. Chen
      Original article citation: Genome Research 17," 1471 - 1477,

    • Categories: Genetics, Biotechnology, and Cell & Molecular Biology
    • Recommended by : Xuegong Zhang on 11/14/2007 01:15PM GMT
      
      This paper presents a major breakthrough in the study of non-coding RNAs in C. elegans, and also stands as an excellent example of the integration of computation analysis and bench experiments.
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  • A G Protein-Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid

    • X. Liu, Y. Yue, B. Li, Y. Nie, W. Li, W.-H. Wu, L. Ma
      Original article citation: Science 315," (2007).

    • Categories: Cell & Molecular Biology
    • Recommended by : Zeng Chi on 11/07/2007 01:55PM GMT
      
      A hormone that controls plant development and survival acts through a member of a receptor family whose other members are pervasive in animal cells.
    • Comment on this subject: 2 comments made

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  • Activity-Dependent Development of Callosal Projections in the Somatosensory Cortex

    • C.-L. Wang, L. Zhang, Y. Zhou, J. Zhou, X.-J. Yang, S.-m. Duan, Z.-Q. Xiong, Y.-Q. Ding
      Original article citation: Journal of Neuroscience 27," (2007).

    • Categories: Developmental Biology, Neuroscience, and Cell & Molecular Biology
    • Recommended by : wei zeng on 11/01/2007 06:13AM GMT
      
      The corpus callosum is the largest commissural system in the mammalian brain, but the mechanisms underlying its development are not well understood. This paper reports that neuronal activity is necessary for the normal development and maintenance of callosal projections in the mouse somatosensory cortex.
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  • Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells

    • Yan-chang SHANG, Shu-hui WANG, Fu XIONG, Cui-ping ZHAO, Fu-ning PENG, Shan-wei FENG, Mei-shan LI, Yong LI, Cheng ZHANG
      Original article citation: Acta Pharmacologica Sinica 28," (2007).

    • Categories: Cell & Molecular Biology and Developmental Biology
    • Recommended by : Clarck Qian Liu on 10/31/2007 06:38AM GMT
      
      Authors provided solid evidences to demonstrate the effects of Wnt3a on mesenchymal stem cell proliferation, differentiation and migration. The data are clearly presented. The activation of canonical Wnt signalling pathway promoted cell proliferation, myogenic differentiation and migration, and inhibited adipogenic differentiation. Authors also analysed the gene profile during the myogenic differentiation and the possible mechanism of adipogenic inhibition.
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  • Insights into the Evolution of the Motilin/Ghrelin-Associated Family and Their Receptors

    • J. He, D. M. Irwin, Y.-p. Zhang
      Original article citation: Molecular Biology and Evolution doi:10.1093/molbev/msm161 (2007)

    • Categories: Ecology & Evolution, Genetics, Neuroscience, and Cell & Molecular Biology
    • Recommended by : yongyi shen on 09/14/2007 07:21AM GMT
      
      According to Darwinian theory, complexity evolves by a stepwise process of elaboration and optimization under natural selection. Simultaneous emergence of more than one element by mutational processes is unlikely, so this would evoke an evolutionary puzzle that how evolutionary processes assemble complex systems that depend on specific interactions among the parts. Based on phylogenetic analyses and molecular inferences, He et al. investigated the evolution of the motilin/ghrelin-associated family and their receptors, and demonstrated that the ghrelin/GHSR system has been maintained and functionally conserved from fish to mammals, whereas motilin-MLNR specificity only evolved as the result of ligand-receptor coevolution after the hormone gene duplicated. Discordance of evolutionary histories for the receptors and ligands indicates that tightly integrated systems can be assembled by combining old molecules that were previously constrained with different ancestral roles, with new ones (generated by gene duplication that represents slight structural variants of an older element). Then they proposed a model for the evolution of novelties in tightly integrated biological systems, which may provide a general explanation for how the molecular interactions critical for life’s complexity emerged in Darwinian fashion after gene duplication.
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  • The upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats

    • Min Zhang, Wen-Bin Li, Jin-Xia Geng, Qing-Jun Li, Xiao-Cai Sun, Xiao-Hui Xian, Jie Qi, Shu-Qin Li
      Original article citation: J Cereb Blood Flow Metab doi:10.1038/sj.jcbfm.9600441 (2007)

    • Categories: Neuroscience and Cell & Molecular Biology
    • Recommended by : Tali Swann-Sternberg on 05/29/2007 08:35PM GMT
      
      This study looks at the upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats. The research took place in China.
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  • Polymorphisms of ACE2 Gene are Associated With Essential Hypertension and Antihypertensive Effects of Captopril in Women

    • X Fan, Y Wang, K Sun, W Zhang, X Yang, S Wang, Y Zhen, J Wang, W Li, Y Han, T Liu, X Wang, J Chen, H Wu, R Hui
      Original article citation: Clin Pharmacol Ther doi:10.1038/sj.clpt.6100214 (2007)

    • Categories: Clinical Medicine, Genetics, and Cell & Molecular Biology
    • Recommended by : Tali Swann-Sternberg on 05/02/2007 07:19PM GMT
      
      This article is about pharmacogenomic based antihypertensive drugs selection, effects and side effects, in rural areas of China.
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  • A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

    • Tong Sun, Yang Gao, Wen Tan, Sufang Ma, Yuankai Shi, Jiarui Yao, Yongli Guo, Ming Yang, Xuemei Zhang, Qingrun Zhang, Changqing Zeng, Dongxin Lin
      Original article citation: Nat Genet doi:10.1038/ng2030 (2007)

    • Categories: Genetics, Cell & Molecular Biology, and Clinical Medicine
    • Recommended by : Myles Axton on 04/23/2007 05:18PM GMT
      
      Evidence that common genetic variants affecting immune function influence susceptibility to multiple cancers.
    • Comment on this subject: 1 comment made

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  • Surviving Endoplasmic Reticulum Stress Is Coupled to Altered Chondrocyte Differentiation and Function

    • Kwok Yeung Tsang, Danny Chan, Deborah Cheslett, Wilson C. W. Chan, Chi Leong So, Ian G. Melhado, Tori W. Y. Chan, Kin Ming Kwan, Ernst B. Hunziker, Yoshihiko Yamada, John F. Bateman, Kenneth M. C. Cheung, Kathryn S. E. Cheah
      Original article citation: Plos Biol 5," (2007).

    • Categories: Developmental Biology, Genetics, Cell & Molecular Biology, and Clinical Medicine
    • Recommended by : Dong-Yan Jin on 04/20/2007 03:32AM GMT
      
      In this study, a transgenic mouse model with 13bp deletion in Col10a1 (13del) was made and characterized. The same mutation has been found in human patients with Schmid metaphyseal chondrodysplasia (SMCD). This work has substantially advanced our understanding of 13del as well as its pathological roles in SMCD. It also creates a valuable mouse model for studying cartilage and bone development. The observations made on expansion of hypertrophic zone and its correlation with activation of ER stress significantly open up the field and provide new avenues for future studies.
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