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User-recommended papers allows you to suggest a paper you would like to see on Nature China. When these papers appear on our site, users may comment and vote on them. To recommend a paper please use this form. Please note that you cannot recommend a paper you have authored. The editors will reject any self-recommendations. All comments and recommendation are checked by the editors and may be edited prior to publication on the site.

• Clinical Medicine

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  • Discussion of posthumous organ donation in Chinese families

    • Anise Man Sze Wu
      Original article citation: Psych., Hlth. & Med. 13," 48 - 54, (2008).

    • Categories: Clinical Medicine
    • Recommended by : Jie Huang on 04/04/2008 04:26PM GMT
      
      A pretty cool investigation about organ donation in China's background. Organ donation is more prevelant in western cultures, at least it's an ordinary topic for them, e.g., when applying for a driver's license, there's a check-box on the application form for you to indicate whether you are willing to donate your organs if "something" happens. In China, it's more of problem with family and social pressure coming from traditional concept. Based on the perspective of psychology, they investigated the factors affecting the likelihood of family discussion about organ donation. It serves socially pragmatic value for medical service.
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  • Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery

    • Wei-Hong Wen, Jia-Yun Liu, Wei-Jun Qin, Jing Zhao, Tao Wang, Lin-Tao Jia, Yan-Ling Meng, Hui Gao, Cai-Fang Xue, Bo-Quan Jin, Li-Bo Yao, Si-Yi Chen, An-Gang Yang
      Original article citation: Hepatology 46," 84 - 94, (2007).

    • Categories: Cell & Molecular Biology, Biotechnology, and Clinical Medicine
    • Recommended by : xue qian on 02/25/2008 09:21AM GMT
      
      This paper demonstrates ScFv-Ck-tP mediated RNA interference executes potent and persistent HBV inhibition. The findings will definitely increase the potential of targeted delivery siRNA therapeutics for clinical application in the therapy of hepatitis B.
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  • SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B

    • C SUN, F ZHANG, X GE, T YAN, X CHEN, X SHI, Q ZHAI
      Original article citation: Cell Metabolism 6," 307 - 319, (2007).

    • Categories: Cell & Molecular Biology, Genetics, and Clinical Medicine
    • Recommended by : yunbiao lu on 02/22/2008 12:37PM GMT
      
      just like the author said: the finding that SIRT1 improves insulin sensitivity has implications toward resolving insulin resistance and type 2 diabetes.
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  • From meridians and acupoints to self-supervision and control system:a hypothesis of the 10th functional system based on anatomical studies of digitized virtual human

    • Lin Yuan, Jun Wang, Chun-lei Wang, Da-wei Yao
      Original article citation: Journal of Southern Medical University 27," 573 - 579, (2007).

    • Categories: Developmental Biology, Ecology & Evolution, and Clinical Medicine
    • Recommended by : Yuan Lingling on 12/19/2007 08:15AM GMT
      
      this actcle not only gave a reasonable explanation to the mechanism of the Chinese acupuncture,but also present a hypothesis of a new functional system which based on anatomical stuides of digitized virtual human.in additional, they created a new subject 'Fasciology',if this hypothesis can be recognized,there will be a bigest new to Traditional Chinese Medicine and based medical research in the world. 'there also have some artcles about this topice have published in some other key magazines.<ACT ANATOMICA SINICA>,<SCIENTIFIC CHINESE> and so on.
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  • A Facile Method for Permanent and Functional Surface Modification of Poly(dimethylsiloxane)

    • Y. Wu, Y. Huang, H. Ma
      Original article citation: J. Am. Chem. Soc. 129," 7226 - 7227, (2007).

    • Categories: Biotechnology, Materials, Chemistry, and Clinical Medicine
    • Recommended by : Jeff Xi on 11/15/2007 01:12AM GMT
      
      This article demonstrated a novel strategy to realize the surface modification of PDMS, which rendered PDMS tunable surface properties, for example, from very hydrophilic to very hydrophobic.
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  • Prevention of neuropathic pain in an animal model of spare nerve injury following oral immunization with recombinant adenovirus serotype 5-mediated NR2B gene transfer

    • G-M Wang, X-B Tian, J-P Chen, S-B Yang, F Gao, H Yang, K An, Y-K Tian
      Original article citation: Gene Ther doi:10.1038/sj.gt.3303025 (2007)

    • Categories: Clinical Medicine, Genetics, Neuroscience, and Biotechnology
    • Recommended by : wei zeng on 11/01/2007 06:27AM GMT
      
      This paper investigated the effect of oral immunization with recombinant adenovirus serotype 5-mediated NR2B gene transfer (rAd5/NR2B) for the modulation of neuropathic pain.
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  • Pharmacokinetics of Isofraxidin in Rat Plasma after Oral Administration of the Extract of Acanthopanax senticosus Using HPLC with Solid Phase Extraction Method

    • Hui Sun, Haitao Lv, Yanmei Zhang, Xijun Wang, Kaishun Bi, Hongxin Cao
      Original article citation: Chemical and Pharmaceutical Bulletin 55," 1291 - 1295, (2007).

    • Categories: Chemistry, Clinical Medicine, and Developmental Biology
    • Recommended by : Linying Du on 09/12/2007 01:13PM GMT
      
      本文首次利用SPE-HPLC-UV法研究天然生物活性成分异秦皮啶不同形式给药后的大鼠体内的药动学行为的差异。研究结果表明，异秦皮啶单体口服给予大鼠后，仅在0.19 h表征一个强吸收峰，且体内延迟时间较短。而以刺五加标准提取物形式口服给予大鼠后，在0.31h和8.70h表征两个强吸收峰，且体内作用时间和生物利用度与单体给药相比显著提升，这或许归功于中药多成分之间的转化与协同作用。从而揭示中药给药形式的有效性和合理性，及中药作用持久的内在规律，也为中药活性的现代评价提供一个全新思路。 本文发表于日本的Chemical and Pharmaceutical Bulletin(SCI 收录)。全文见Chem. Pharm. Bull. 55(9) 1291—1295 (2007)
    • Comment on this subject: 1 comment made

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  • Polymorphisms of ACE2 Gene are Associated With Essential Hypertension and Antihypertensive Effects of Captopril in Women

    • X Fan, Y Wang, K Sun, W Zhang, X Yang, S Wang, Y Zhen, J Wang, W Li, Y Han, T Liu, X Wang, J Chen, H Wu, R Hui
      Original article citation: Clin Pharmacol Ther doi:10.1038/sj.clpt.6100214 (2007)

    • Categories: Clinical Medicine, Genetics, and Cell & Molecular Biology
    • Recommended by : Tali Swann-Sternberg on 05/02/2007 07:19PM GMT
      
      This article is about pharmacogenomic based antihypertensive drugs selection, effects and side effects, in rural areas of China.
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  • A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

    • Tong Sun, Yang Gao, Wen Tan, Sufang Ma, Yuankai Shi, Jiarui Yao, Yongli Guo, Ming Yang, Xuemei Zhang, Qingrun Zhang, Changqing Zeng, Dongxin Lin
      Original article citation: Nat Genet doi:10.1038/ng2030 (2007)

    • Categories: Genetics, Cell & Molecular Biology, and Clinical Medicine
    • Recommended by : Myles Axton on 04/23/2007 05:18PM GMT
      
      Evidence that common genetic variants affecting immune function influence susceptibility to multiple cancers.
    • Comment on this subject: 1 comment made

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  • Surviving Endoplasmic Reticulum Stress Is Coupled to Altered Chondrocyte Differentiation and Function

    • Kwok Yeung Tsang, Danny Chan, Deborah Cheslett, Wilson C. W. Chan, Chi Leong So, Ian G. Melhado, Tori W. Y. Chan, Kin Ming Kwan, Ernst B. Hunziker, Yoshihiko Yamada, John F. Bateman, Kenneth M. C. Cheung, Kathryn S. E. Cheah
      Original article citation: Plos Biol 5," (2007).

    • Categories: Developmental Biology, Genetics, Cell & Molecular Biology, and Clinical Medicine
    • Recommended by : Dong-Yan Jin on 04/20/2007 03:32AM GMT
      
      In this study, a transgenic mouse model with 13bp deletion in Col10a1 (13del) was made and characterized. The same mutation has been found in human patients with Schmid metaphyseal chondrodysplasia (SMCD). This work has substantially advanced our understanding of 13del as well as its pathological roles in SMCD. It also creates a valuable mouse model for studying cartilage and bone development. The observations made on expansion of hypertrophic zone and its correlation with activation of ER stress significantly open up the field and provide new avenues for future studies.
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