User recommended papers
User-recommended papers allows you to suggest a paper you would like to see on Nature China. When these papers appear on our site, users may comment and vote on them. To recommend a paper please use this form. Please note that you cannot recommend a paper you have authored. The editors will reject any self-recommendations. All comments and recommendation are checked by the editors and may be edited prior to publication on the site.
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Developmental Biology
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Different effects of mild and severe seizures on hippocampal neurogenesis in adult rats
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Original article citation: Hippocampus doi:10.1002/hipo.20409 - Categories: Neuroscience, Cell & Molecular Biology, and Developmental Biology
- Recommended by : Jie Huang on 02/21/2008 03:47PM GMT
Hippocampus is known to be one site of continuing neurogenesis into adulthood for humans and other mammals, which provides possible compensatory and rehabilitative mechanisms for some brain injuries. Based on previous knowledge about epileptic seizures effect on neurogenesis in dentate gyrus (DG), researchers in this study examined seizure severity's influence in this process on rats. It appeared though both mild and severe seizures promoted mitotic activity in DG, difference in severity were driving neuron proliferation and migration into two distinctive directions. On the other hand, it hints at limitations of hippocampus' postnatal neurogenesis. - Comment on this subject: 0 comments made
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From meridians and acupoints to self-supervision and control system:a hypothesis of the 10th functional system based on anatomical studies of digitized virtual human
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Original article citation: Journal of Southern Medical University 27," 573 - 579, (2007). - Categories: Developmental Biology, Ecology & Evolution, and Clinical Medicine
- Recommended by : Yuan Lingling on 12/19/2007 08:15AM GMT
this actcle not only gave a reasonable explanation to the mechanism of the Chinese acupuncture,but also present a hypothesis of a new functional system which based on anatomical stuides of digitized virtual human.in additional, they created a new subject 'Fasciology',if this hypothesis can be recognized,there will be a bigest new to Traditional Chinese Medicine and based medical research in the world. 'there also have some artcles about this topice have published in some other key magazines.<ACT ANATOMICA SINICA>,<SCIENTIFIC CHINESE> and so on. - Comment on this subject: 0 comments made
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Activity-Dependent Development of Callosal Projections in the Somatosensory Cortex
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Original article citation: Journal of Neuroscience 27," (2007). - Categories: Developmental Biology, Neuroscience, and Cell & Molecular Biology
- Recommended by : wei zeng on 11/01/2007 06:13AM GMT
The corpus callosum is the largest commissural system in the mammalian brain, but the mechanisms underlying its development are not well understood. This paper reports that neuronal activity is necessary for the normal development and maintenance of callosal projections in the mouse somatosensory cortex. - Comment on this subject: 0 comments made
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Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells
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Original article citation: Acta Pharmacologica Sinica 28," (2007). - Categories: Cell & Molecular Biology and Developmental Biology
- Recommended by : Clarck Qian Liu on 10/31/2007 06:38AM GMT
Authors provided solid evidences to demonstrate the effects of Wnt3a on mesenchymal stem cell proliferation, differentiation and migration. The data are clearly presented. The activation of canonical Wnt signalling pathway promoted cell proliferation, myogenic differentiation and migration, and inhibited adipogenic differentiation. Authors also analysed the gene profile during the myogenic differentiation and the possible mechanism of adipogenic inhibition. - Comment on this subject: 0 comments made
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Pharmacokinetics of Isofraxidin in Rat Plasma after Oral Administration of the Extract of Acanthopanax senticosus Using HPLC with Solid Phase Extraction Method
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Original article citation: Chemical and Pharmaceutical Bulletin 55," 1291 - 1295, (2007). - Categories: Chemistry, Clinical Medicine, and Developmental Biology
- Recommended by : Linying Du on 09/12/2007 01:13PM GMT
本文首次利用SPE-HPLC-UV法研究天然生物活性成分异秦皮啶不同形式给药后的大鼠体内的药动学行为的差异。研究结果表明，异秦皮啶单体口服给予大鼠后，仅在0.19 h表征一个强吸收峰，且体内延迟时间较短。而以刺五加标准提取物形式口服给予大鼠后，在0.31h和8.70h表征两个强吸收峰，且体内作用时间和生物利用度与单体给药相比显著提升，这或许归功于中药多成分之间的转化与协同作用。从而揭示中药给药形式的有效性和合理性，及中药作用持久的内在规律，也为中药活性的现代评价提供一个全新思路。 本文发表于日本的Chemical and Pharmaceutical Bulletin(SCI 收录)。全文见Chem. Pharm. Bull. 55(9) 1291—1295 (2007) - Comment on this subject: 1 comment made
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Surviving Endoplasmic Reticulum Stress Is Coupled to Altered Chondrocyte Differentiation and Function
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Original article citation: Plos Biol 5," (2007). - Categories: Developmental Biology, Genetics, Cell & Molecular Biology, and Clinical Medicine
- Recommended by : Dong-Yan Jin on 04/20/2007 03:32AM GMT
In this study, a transgenic mouse model with 13bp deletion in Col10a1 (13del) was made and characterized. The same mutation has been found in human patients with Schmid metaphyseal chondrodysplasia (SMCD). This work has substantially advanced our understanding of 13del as well as its pathological roles in SMCD. It also creates a valuable mouse model for studying cartilage and bone development. The observations made on expansion of hypertrophic zone and its correlation with activation of ER stress significantly open up the field and provide new avenues for future studies. - Comment on this subject: 0 comments made
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