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User-recommended papers allows you to suggest a paper you would like to see on Nature China. When these papers appear on our site, users may comment and vote on them. To recommend a paper please use this form. Please note that you cannot recommend a paper you have authored. The editors will reject any self-recommendations. All comments and recommendation are checked by the editors and may be edited prior to publication on the site.

• Genetics

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  • Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding

    • 
      Original article citation: EMBO J doi:10.1038/emboj.2008.240 (2008)

    • Categories: Cell & Molecular Biology and Genetics
    • Recommended by : Alison Wrigley on 11/21/2008 11:05AM GMT
      
      Escherichia coli UvrD is a non-ring-shaped model helicase, displaying a 3'–5' polarity in DNA unwinding. Using a transverse magnetic tweezer and DNA hairpins, we measured the unwinding kinetics of UvrD at various DNA-destabilizing forces. The multiform patterns of unwinding bursts and the distributions of the off-times favour the mechanism that UvrD unwinds DNA as a dimer. The two subunits of the dimer coordinate to unwind DNA processively. They can jointly switch strands and translocate backwards on the other strand to allow slow (approx40 bp/s) rewinding, or unbind simultaneously to allow quick rehybridization. Partial dissociation of the dimer results in pauses in the middle of the unwinding or increases the translocation rate from approx40 to approx150 nt/s in the middle of the rewinding. Moreover, the unwinding rate was surprisingly found to decrease from approx45 to approx10 bp/s when the force is increased from 2 to 12 pN. The results lead to a strained-inchworm mechanism in which a conformational change that bends and tenses the ssDNA is required to activate the dimer.
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  • Chloroplast phylogeography of Dipentodon (Dipentodontaceae) in southwest China and northern Vietnam

    • QING-JUN YUAN, ZHI-YONG ZHANG, HUA PENG, SONG GE
      Original article citation: Mol Ecol 17," 1054 - 1065, (2008).

    • Categories: Ecology & Evolution, Genetics, and Cell & Molecular Biology
    • Recommended by : zhang xuemei on 04/12/2008 02:13AM GMT
      
      This is an excellent and meaningful papar involving the conceivably most complicated evolutionary history in the southeast Tibetan Plateau,where the topography and climate are extremely complex. The incumbent target is also an attractive monotypic genus Dipentodon sinicus. By using chloroplast sequences, important results were obtained providing new insights to the evolution of biodiversity on the Tibetan Plateau and adiacent areas. Also, a historical framework for the conservation of biodiversity in this area was given. In summary, it is an informative and helpful paper for understanding the Dipentodon and Tibetan Plateau.
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  • SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B

    • C SUN, F ZHANG, X GE, T YAN, X CHEN, X SHI, Q ZHAI
      Original article citation: Cell Metabolism 6," 307 - 319, (2007).

    • Categories: Cell & Molecular Biology, Genetics, and Clinical Medicine
    • Recommended by : yunbiao lu on 02/22/2008 12:37PM GMT
      
      just like the author said: the finding that SIRT1 improves insulin sensitivity has implications toward resolving insulin resistance and type 2 diabetes.
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  • MiPred: classification of real and pseudo microRNA precursors using random forest prediction model with combined features

    • P. Jiang, H. Wu, W. Wang, W. Ma, X. Sun, Z. Lu
      Original article citation: Nucleic Acids Research 35," W339 - W344,

    • Categories: Genetics
    • Recommended by : xinan yang on 11/21/2007 07:34AM GMT
      
      useful tools development for microRNA prediction
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  • Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray

    • H. He, J. Wang, T. Liu, X. S. Liu, T. Li, Y. Wang, Z. Qian, H. Zheng, X. Zhu, T. Wu, B. Shi, W. Deng, W. Zhou, G. Skogerbo, R. Chen
      Original article citation: Genome Research 17," 1471 - 1477,

    • Categories: Genetics, Biotechnology, and Cell & Molecular Biology
    • Recommended by : Xuegong Zhang on 11/14/2007 01:15PM GMT
      
      This paper presents a major breakthrough in the study of non-coding RNAs in C. elegans, and also stands as an excellent example of the integration of computation analysis and bench experiments.
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  • Prevention of neuropathic pain in an animal model of spare nerve injury following oral immunization with recombinant adenovirus serotype 5-mediated NR2B gene transfer

    • G-M Wang, X-B Tian, J-P Chen, S-B Yang, F Gao, H Yang, K An, Y-K Tian
      Original article citation: Gene Ther doi:10.1038/sj.gt.3303025 (2007)

    • Categories: Clinical Medicine, Genetics, Neuroscience, and Biotechnology
    • Recommended by : wei zeng on 11/01/2007 06:27AM GMT
      
      This paper investigated the effect of oral immunization with recombinant adenovirus serotype 5-mediated NR2B gene transfer (rAd5/NR2B) for the modulation of neuropathic pain.
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  • Insights into the Evolution of the Motilin/Ghrelin-Associated Family and Their Receptors

    • J. He, D. M. Irwin, Y.-p. Zhang
      Original article citation: Molecular Biology and Evolution doi:10.1093/molbev/msm161 (2007)

    • Categories: Ecology & Evolution, Genetics, Neuroscience, and Cell & Molecular Biology
    • Recommended by : yongyi shen on 09/14/2007 07:21AM GMT
      
      According to Darwinian theory, complexity evolves by a stepwise process of elaboration and optimization under natural selection. Simultaneous emergence of more than one element by mutational processes is unlikely, so this would evoke an evolutionary puzzle that how evolutionary processes assemble complex systems that depend on specific interactions among the parts. Based on phylogenetic analyses and molecular inferences, He et al. investigated the evolution of the motilin/ghrelin-associated family and their receptors, and demonstrated that the ghrelin/GHSR system has been maintained and functionally conserved from fish to mammals, whereas motilin-MLNR specificity only evolved as the result of ligand-receptor coevolution after the hormone gene duplicated. Discordance of evolutionary histories for the receptors and ligands indicates that tightly integrated systems can be assembled by combining old molecules that were previously constrained with different ancestral roles, with new ones (generated by gene duplication that represents slight structural variants of an older element). Then they proposed a model for the evolution of novelties in tightly integrated biological systems, which may provide a general explanation for how the molecular interactions critical for life’s complexity emerged in Darwinian fashion after gene duplication.
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  • • 23+ votes

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  • A novel redox-potential-based screening strategy for rapid isolation of Klebsiella pneumoniae mutants with enhanced 1,3-propanediol producing capability

    • C. Du, Y. Zhang, Y. Li, Z. Cao
      Original article citation: Applied and Environmental Microbiology doi:10.1128/AEM.02857-06 (2007)

    • Categories: Biotechnology and Genetics
    • Recommended by : Zheng-Hong Xu on 06/06/2007 09:42AM GMT
      
      In many years the Chinese Industrial Biotechnologists spent a lot of energy on increasing the production level of useful metabolites. However, they rarely develop new methodology which would result in a revolutionary development of a certain biotechnological process. Du et al. describes a novel redox-potential-based screening strategy for rapid isolation of Klebsiella pneumoniae mutants with enhanced 1,3-propanediol (a bulk chemical) production capability. The result provides a novel screening strategy which could be helpful to screen/develop strains involved in the oxidoreduction biosynthesis, which is of great potential for industrial biotechnology. The other significance of this study is that it is a typical hypothesis-driven research, which is rarely found in the industrial biotechnology research field in China. The acceptance of this nice article by Applied & Environmental Microbiology symbolizes that the industrial biotechnologists are more focusing on the fundamental research area, e. g. development of novel methodologies. This is important for achieving a bright future for China’s bioeconomy.
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  • • 2+ votes

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  • Polymorphisms of ACE2 Gene are Associated With Essential Hypertension and Antihypertensive Effects of Captopril in Women

    • X Fan, Y Wang, K Sun, W Zhang, X Yang, S Wang, Y Zhen, J Wang, W Li, Y Han, T Liu, X Wang, J Chen, H Wu, R Hui
      Original article citation: Clin Pharmacol Ther doi:10.1038/sj.clpt.6100214 (2007)

    • Categories: Clinical Medicine, Genetics, and Cell & Molecular Biology
    • Recommended by : Tali Swann-Sternberg on 05/02/2007 07:19PM GMT
      
      This article is about pharmacogenomic based antihypertensive drugs selection, effects and side effects, in rural areas of China.
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  • • 3+ votes

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  • A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

    • Tong Sun, Yang Gao, Wen Tan, Sufang Ma, Yuankai Shi, Jiarui Yao, Yongli Guo, Ming Yang, Xuemei Zhang, Qingrun Zhang, Changqing Zeng, Dongxin Lin
      Original article citation: Nat Genet doi:10.1038/ng2030 (2007)

    • Categories: Genetics, Cell & Molecular Biology, and Clinical Medicine
    • Recommended by : Myles Axton on 04/23/2007 05:18PM GMT
      
      Evidence that common genetic variants affecting immune function influence susceptibility to multiple cancers.
    • Comment on this subject: 1 comment made

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