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User-recommended papers allows you to suggest a paper you would like to see on Nature India. When these papers appear on our site, users may comment and vote on them. To recommend a paper please use this form. Please note that you cannot recommend a paper you have authored. The editors will reject any self-recommendations. All comments and recommendation are checked by the editors and may be edited prior to publication on the site.

• 55 votes

  Biotechnology

  • • 51+ votes

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  • Hairpin RNA-Mediated Strategies for Silencing of

    • S.V. Ramesh, A.K. Mishra, S. Praveen
      Original article citation: Oligonucleotides 17," 251 - 257, (2007).

    • Categories: Biotechnology and Cell & Molecular Biology
    • Recommended by : Praveen Mehrotra on 02/02/2008 01:29PM GMT
      
      Careful designing of hairpin strategies will not only help in developing trait stable transgenics but will also help in developing broad spectrum resistance against viruses.
    • Comment on this subject: 2 comments made

• 30 votes

  Biotechnology

  • • 29+ votes

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  • Small RNA mediated silencing to target Tomato leaf curl virus

    • Shelly Praveen, S. V. Ramesh, Vikas Koundal, Anil Mishra, R. K. Jain
      Original article citation: J. of Plant Interactions 2," 213 - 218, (2007).

    • Categories: Biotechnology and Cell & Molecular Biology
    • Recommended by : Praveen Mehrotra on 02/25/2008 05:39PM GMT
      
      Targeting viral genome through small RNA mediated strategy is an important tool for developing resistance. Viral derived siRNAs, if delivered through host (indigenous) RNAi machinery in the form of artificial micro RNA, is more effective in producing small RNAs and ultimately the resistance response.
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• 27 votes

  Clinical Medicine

  • • 24+ votes

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  • Anomalous venous blood flow and iron deposition in multiple sclerosis

    • 
      Original article citation: J Cereb Blood Flow Metab doi:10.1038/jcbfm.2009.180 (2009)

    • Categories: Clinical Medicine, Cell & Molecular Biology, Genetics, and Neuroscience
    • Recommended by : Dr Uttara Bayani on 10/15/2009 05:33PM GMT
      
      First paper highlighting the physiological causes of neurodegeneration in Multiple Sclerosis MS. Authors have mentioned that disturbed microcirculation in jugular vein (due to pressure changes), leads to CCSVI, subsequent iron depositions in cerebrospinal region and lost neuronal motor function. The authors had actually shown in patients that corrective surgery has tremendous capacity to restores motor function in almost paralyzed MS patients.
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• 22 votes

  Materials

  • • 21+ votes

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  • Experimental Evidence of Zero Forward Scattering by Magnetic Spheres

    • R. V. Mehta, Rajesh Patel, Rucha Desai, R. V. Upadhyay, Kinnari Parekh
      Original article citation: Phys. Rev. Lett. 96," (2006).

    • Categories: Materials and Physics
    • Recommended by : Nilanjan Dey on 03/14/2008 10:22AM GMT
      
      The research shows that combination of magnetic sphere and ferrofluid will be helpful in designing tunable photonic devices.
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• 31 votes

  Biotechnology

  • • 25+ votes

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  • Host-generated double stranded RNA induces RNAi in plant-parasitic nematodes and protects the host from infection

    • B YADAV, K VELUTHAMBI, K SUBRAMANIAM
      Original article citation: Molecular and Biochemical Parasitology 148," 219 - 222, (2006).

    • Categories: Biotechnology and Cell & Molecular Biology
    • Recommended by : Keerti S. Rathore on 01/17/2008 02:52PM GMT
      
      The study represents a significant piece of research. It shows a novel way to control the problem of parasitic nematodes using the RNAi technology. It is the first of its kind of study showing clearly that just as in the case of C. elegans, vital genes can be silenced in parasitic nematodes by ingestion of double stranded RNA/siRNA.
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• 18 votes

  Biotechnology

  • • 17+ votes

      1- votes

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  • Contaminating insert degradation by preincubation colony PCR: A method for avoiding false positives in transformant screening

    • V AGRAWAL, N ROY
      Original article citation: Analytical Biochemistry 375," 159 - 161, (2008).

    • Categories: Biotechnology and Cell & Molecular Biology
    • Recommended by : sumit deswal on 03/26/2008 10:45AM GMT
      
      As the title suggests, the paper presents a fast and cost effective method for degrading contaminating insert for transformant screening. Surely, a useful advancement for any molecular biology lab.
    • Comment on this subject: 2 comments made

• 17 votes

  Cell & Molecular Biology

  • • 15+ votes

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  • Molecular Analysis of a Leprosy Immunotherapeutic Bacillus Provides Insights into Mycobacterium Evolution

    • Niyaz Ahmed, Vikram Saini, Saurabh Raghuvanshi, Jitendra P. Khurana, Akhilesh K. Tyagi, Anil K. Tyagi, Seyed E. Hasnain, Zulfiqar Bhutta
      Original article citation: PLoS ONE 2," e968 ,

    • Categories: Cell & Molecular Biology, Biotechnology, Ecology & Evolution, and Genetics
    • Recommended by : Rajesh Ghangal on 02/28/2008 08:12AM GMT
      
      This paper, besides being explicitly written, is also the first report on evolution of opportunistic mycobacterium which are the leading cause of death among immune compromised hosts including HIV patients.
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• 13 votes

  Cell & Molecular Biology

  • • 13+ votes

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  • Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence

    • Jitesh P. Iyer, Anees Kaprakkaden, Manohar L. Choudhary, Chandrima Shaha
      Original article citation: Mol Microbiol 68," 372 - 391, (2008).

    • Categories: Cell & Molecular Biology and Clinical Medicine
    • Recommended by : Anand Giddabasappa CS on 03/31/2008 05:58AM GMT
      
      Leishmaniasis or kala-azar is a parasitic disease that has re-emerged in India. Epidemiological studies show that 90% of the cases occur in India. Though the government of India has employed many strategies for prevention and treatment of this disease, resistance to the DDT and also drugs has posed a major challenge. Understanding of the physiology of the parasite and also identification of unique drug targets in the parasite can be a major break-through in this area of science. Iyer et al. have made a big effort in this process. Leishmania donovani the causative agent of Leishmaniasis utilizes a unique pathway present only in the parasite to detoxify the free radicals generated by the host macrophages. Iyer et al. have shown that tryparedoxin peroxidase is the key enzyme in this pathway. This article shows that tryparedoxin peroxidase is required for the parasite’s survival and virulence. Hence this can be a unique and an excellent target for treating Leishmaniasis.
    • Comment on this subject: 2 comments made

• 14 votes

  Developmental Biology

  • • 13+ votes

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  • Gamete formation without meiosis in Arabidopsis

    • Maruthachalam Ravi, Mohan P. A. Marimuthu, Imran Siddiqi
      Original article citation: Nature doi:10.1038/nature06557 (2008)

    • Categories: Developmental Biology and Genetics
    • Recommended by : Pranjal Yadava on 02/21/2008 12:21PM GMT
      
      Indian research published in Nature!
    • Comment on this subject: 0 comments made

• 14 votes

  Biotechnology

  • • 13+ votes

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  • The biological sciences in India: Aiming high for the future

    • 
      Original article citation: The Journal of Cell Biology 184," 342 - 353,

    • Categories: Biotechnology
    • Recommended by : Nagadenahalli Siddappa on 02/12/2009 02:58AM GMT
      
      Very exiciting paper written about today's Indian life science, challlenges, future. Every Indian life scientist must read and learn how to become leader in the field to bring Indian life science forward.
    • Comment on this subject: 1 comment made