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User-recommended papers allows you to suggest a paper you would like to see on Nature India. When these papers appear on our site, users may comment and vote on them. To recommend a paper please use this form. Please note that you cannot recommend a paper you have authored. The editors will reject any self-recommendations. All comments and recommendation are checked by the editors and may be edited prior to publication on the site.

• Cell & Molecular Biology

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  • Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention

    • Niyaz Ahmed, Ulrich Dobrindt, Jörg Hacker, Seyed E. Hasnain
      Original article citation: Nat Rev Micro 6," 387 - 394, (2008).

    • Categories: Cell & Molecular Biology and Ecology & Evolution
    • Recommended by : Irshad AHMED on 04/17/2008 08:30AM GMT
      
      Its a good opinionated piece which I think is the first commissioned article in a Nature journal from CDFD. The paper systematically highlights how genome evolution in pathogenic bacteria can be put to action in healthcare.
    • Comment on this subject: 2 comments made

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  • Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population

    • Swapnil Sinha, Shrawan K Mishra, Shweta Sharma, Phani K Patibandla, Prashant K Mallick, Surya K Sharma, Sanjib Mohanty, Sudhanshu S Pati, Saroj K Mishra, Bheshaj K Ramteke, R M Bhatt, Hema Joshi, Aditya P Dash, Ramesh C Ahuja, Shally Awasthi, Indian Genome Variation Consortium, Vimala Venkatesh, Saman Habib
      Original article citation: Malar J 7," 13 , (2008).

    • Categories: Cell & Molecular Biology
    • Recommended by : Seema Mishra on 04/16/2008 11:24AM GMT
      
      The work published is an account of first genetic association analyses of the two immuno-regulatory molecules, TNF and FCGR2A specific SNPs with cytokine levels and severity/resistance to P. falciparum malaria in the Indian population.
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  • Contaminating insert degradation by preincubation colony PCR: A method for avoiding false positives in transformant screening

    • Vineet Agrawal
      Original article citation: Analytical Biochemistry 375," 159 - 161, (2008).

    • Categories: Biotechnology and Cell & Molecular Biology
    • Recommended by : Shruti Agrawal on 04/01/2008 12:10PM GMT
      
      Colony PCR is an easy technique for quick screening of transformants and hence is used in many recombinant laboratories. However the major disadvantage is occurence of false positives. Though efforts have been done before to address this problem, but solution limits this technique by mandatory requirement of flanking vector oligos, which many a times is not possible. This work imparts universatility by removing this limitation and provides a quick method devoid of false positives for any cloning vector.
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  • Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence

    • Jitesh P. Iyer, Anees Kaprakkaden, Manohar L. Choudhary, Chandrima Shaha
      Original article citation: Mol Microbiol 68," 372 - 391, (2008).

    • Categories: Cell & Molecular Biology and Clinical Medicine
    • Recommended by : Anand Giddabasappa CS on 03/31/2008 05:58AM GMT
      
      Leishmaniasis or kala-azar is a parasitic disease that has re-emerged in India. Epidemiological studies show that 90% of the cases occur in India. Though the government of India has employed many strategies for prevention and treatment of this disease, resistance to the DDT and also drugs has posed a major challenge. Understanding of the physiology of the parasite and also identification of unique drug targets in the parasite can be a major break-through in this area of science. Iyer et al. have made a big effort in this process. Leishmania donovani the causative agent of Leishmaniasis utilizes a unique pathway present only in the parasite to detoxify the free radicals generated by the host macrophages. Iyer et al. have shown that tryparedoxin peroxidase is the key enzyme in this pathway. This article shows that tryparedoxin peroxidase is required for the parasite’s survival and virulence. Hence this can be a unique and an excellent target for treating Leishmaniasis.
    • Comment on this subject: 2 comments made

  • • 17+ votes

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  • Contaminating insert degradation by preincubation colony PCR: A method for avoiding false positives in transformant screening

    • V AGRAWAL, N ROY
      Original article citation: Analytical Biochemistry 375," 159 - 161, (2008).

    • Categories: Biotechnology and Cell & Molecular Biology
    • Recommended by : sumit deswal on 03/26/2008 10:45AM GMT
      
      As the title suggests, the paper presents a fast and cost effective method for degrading contaminating insert for transformant screening. Surely, a useful advancement for any molecular biology lab.
    • Comment on this subject: 2 comments made

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  • Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain

    • Saurabh Kumar Singh, Rachna Hora, Hassan Belrhali, Chetan E. Chitnis, Amit Sharma
      Original article citation: Nature 439," 741 - 744, (2006).

    • Categories: Cell & Molecular Biology
    • Recommended by : Nilanjan Dey on 03/14/2008 09:57AM GMT
      
      The research is interesting because the insights may affect the development of new prophylactic and therapeutic strategies.
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  • • 15+ votes

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  • Molecular Analysis of a Leprosy Immunotherapeutic Bacillus Provides Insights into Mycobacterium Evolution

    • Niyaz Ahmed, Vikram Saini, Saurabh Raghuvanshi, Jitendra P. Khurana, Akhilesh K. Tyagi, Anil K. Tyagi, Seyed E. Hasnain, Zulfiqar Bhutta
      Original article citation: PLoS ONE 2," e968 ,

    • Categories: Cell & Molecular Biology, Biotechnology, Ecology & Evolution, and Genetics
    • Recommended by : Rajesh Ghangal on 02/28/2008 08:12AM GMT
      
      This paper, besides being explicitly written, is also the first report on evolution of opportunistic mycobacterium which are the leading cause of death among immune compromised hosts including HIV patients.
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  • • 29+ votes

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  • Small RNA mediated silencing to target Tomato leaf curl virus

    • Shelly Praveen, S. V. Ramesh, Vikas Koundal, Anil Mishra, R. K. Jain
      Original article citation: J. of Plant Interactions 2," 213 - 218, (2007).

    • Categories: Biotechnology and Cell & Molecular Biology
    • Recommended by : Praveen Mehrotra on 02/25/2008 05:39PM GMT
      
      Targeting viral genome through small RNA mediated strategy is an important tool for developing resistance. Viral derived siRNAs, if delivered through host (indigenous) RNAi machinery in the form of artificial micro RNA, is more effective in producing small RNAs and ultimately the resistance response.
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  • Support Vector Machine-based method for predicting subcellular localization of mycobacterial proteins using evolutionary information and motifs

    • Mamoon Rashid, Sudipto Saha, Gajendra PS Raghava
      Original article citation: BMC Bioinformatics 8," 337 , (2007).

    • Categories: Cell & Molecular Biology and Biotechnology
    • Recommended by : Nitish Mishra on 02/09/2008 05:16AM GMT
      
      A new subcellular class of mycobacterial proteins named "membrane-attached by lipid anchor" has been introduced for the first time.
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  • Host–virus genome interactions: macro roles for microRNAs

    • Vinod Scaria, Manoj Hariharan, Beena Pillai, Souvik Maiti, Samir K. Brahmachari
      Original article citation: Cell Microbiol 9," 2784 - 2794, (2007).

    • Categories: Cell & Molecular Biology, Biotechnology, Clinical Medicine, and Genetics
    • Recommended by : Klein K on 02/08/2008 05:34AM GMT
      
      This is an interesting review describing the models of host-virus interactions mediated through microRNAs.
    • Comment on this subject: 0 comments made