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User-recommended papers allows you to suggest a paper you would like to see on Nature India. When these papers appear on our site, users may comment and vote on them. To recommend a paper please use this form. Please note that you cannot recommend a paper you have authored. The editors will reject any self-recommendations. All comments and recommendation are checked by the editors and may be edited prior to publication on the site.

• Clinical Medicine

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  • Development and Characterization of 99mTc-timolol Maleate for Evaluating Efficacy of In Situ Ocular Drug Delivery System

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      Original article citation: AAPS PharmSciTech 10," 540 - 546, (2009).

    • Categories: Clinical Medicine, Chemistry, Developmental Biology, and Materials
    • Recommended by : Aarti Sharma on 11/14/2009 08:51AM GMT
      
      This paper starts with the process of radiolabelling then developing hydrogel and finally its utilization as a non invasive method in evaluation of ocular systems. The paper is a combination of nanotechnology, Pharmaceutical sciences and nuclear medicine. Its very rare to see such versatile combination.
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  • Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery

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      Original article citation: Nanomedicine: Nanotechnology, Biology and Medicine doi:10.1016/j.nano.2009.10.004

    • Categories: Clinical Medicine, Developmental Biology, and Materials
    • Recommended by : Aarti Sharma on 11/14/2009 08:47AM GMT
      
      The paper is a combination of nanotechnology, Pharmaceutical sciences and nuclear medicine. Its very rare to see such versatile combination. The article is presented in very simple language. It took up a very common ocular drug delivery problem and try to resolve it using nanotechnology.Combination of drug and polymer is also not covered else where. its the first attempt.
    • Comment on this subject: 1 comment made

  • • 24+ votes

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  • Anomalous venous blood flow and iron deposition in multiple sclerosis

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      Original article citation: J Cereb Blood Flow Metab doi:10.1038/jcbfm.2009.180 (2009)

    • Categories: Clinical Medicine, Cell & Molecular Biology, Genetics, and Neuroscience
    • Recommended by : Dr Uttara Bayani on 10/15/2009 05:33PM GMT
      
      First paper highlighting the physiological causes of neurodegeneration in Multiple Sclerosis MS. Authors have mentioned that disturbed microcirculation in jugular vein (due to pressure changes), leads to CCSVI, subsequent iron depositions in cerebrospinal region and lost neuronal motor function. The authors had actually shown in patients that corrective surgery has tremendous capacity to restores motor function in almost paralyzed MS patients.
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  • • 4+ votes

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  • Spinal Cord Repair: Bridging the Divide

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      Original article citation: Neurorehabilitation and Neural Repair 22," 429 - 437,

    • Categories: Neuroscience, Cell & Molecular Biology, and Clinical Medicine
    • Recommended by : NAGESH SHANBHAG on 05/05/2009 04:46PM GMT
      
      Unless the intrinsic and extrinsic mechanisms which are involved in the axonal regeneration post-SCI are critically deciphered, it would not lead to a substantial long-term functional recovery in the patients,despite supportive and rehabilitative strategies.
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  • • 6+ votes

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  • FishMap: A Community Resource for Zebrafish Genomics

    • Rajeshwari Meli, Abhiranjan Prasad, Ashok Patowary, Mukesh K. Lalwani, Jayant Maini, Meenakshi Sharma, Angom Ramcharan Singh, Gaurav Kumar, Vaibhav Jadhav, Vinod Scaria, Sridhar Sivasubbu
      Original article citation: Zebrafish 5," 125 - 130, (2008).

    • Categories: Biotechnology, Neuroscience, Clinical Medicine, and Genetics
    • Recommended by : Klein K on 06/18/2008 02:49AM GMT
      
      This is one of the largest Zebrafish genomics resource available and is a starting point for the community annotation initiatives in Zebrafish genome.
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  • Sphingomyelin Functions as a Novel Receptor for Helicobacter pylori VacA

    • Vijay R. Gupta, Hetal K. Patel, Sean S. Kostolansky, Roberto A. Ballivian, Joseph Eichberg, Steven R. Blanke, Partho Ghosh
      Original article citation: PLoS Pathogens 4," e1000073 ,

    • Categories: Cell & Molecular Biology and Clinical Medicine
    • Recommended by : Anand Giddabasappa CS on 05/25/2008 07:05AM GMT
      
      Helicobacter pylori is a gastric pathogen that causes gastric and duodenal ulcer and even gastric carcinoma. VacA, a vaculating cytotoxin secreted by this pathogen is responsible for this toxic action on the host cell. Though VacA was known to interact with the cell membrane of the host (gastric epithelium), the internalization mechanisms were unknown. This paper shows that VacA binds to an unusual receptor called sphingomyelin. Sphingomyelin, a membrane lipid acts as the receptor on the host cell and facilitates binding and internalization of the cytotoxin. This article provides the molecular basis for the binding and action of VacA. Further, it also sheds light on the role of lipid rafts as target to block the pathogenic effects of H. pylori.
    • Comment on this subject: 0 comments made

  • • 3+ votes

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  • Genetic landscape of the people of India: a canvas for disease gene exploration

    • Indian Genome Variation Consortium
      Original article citation: Journal of Genetics (2008)

    • Categories: Genetics, Biotechnology, and Clinical Medicine
    • Recommended by : Klein K on 04/12/2008 08:18AM GMT
      
      This is the first comprehensive analysis of the genetic landscape of the Indian population
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  • • 13+ votes

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  • Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence

    • Jitesh P. Iyer, Anees Kaprakkaden, Manohar L. Choudhary, Chandrima Shaha
      Original article citation: Mol Microbiol 68," 372 - 391, (2008).

    • Categories: Cell & Molecular Biology and Clinical Medicine
    • Recommended by : Anand Giddabasappa CS on 03/31/2008 05:58AM GMT
      
      Leishmaniasis or kala-azar is a parasitic disease that has re-emerged in India. Epidemiological studies show that 90% of the cases occur in India. Though the government of India has employed many strategies for prevention and treatment of this disease, resistance to the DDT and also drugs has posed a major challenge. Understanding of the physiology of the parasite and also identification of unique drug targets in the parasite can be a major break-through in this area of science. Iyer et al. have made a big effort in this process. Leishmania donovani the causative agent of Leishmaniasis utilizes a unique pathway present only in the parasite to detoxify the free radicals generated by the host macrophages. Iyer et al. have shown that tryparedoxin peroxidase is the key enzyme in this pathway. This article shows that tryparedoxin peroxidase is required for the parasite’s survival and virulence. Hence this can be a unique and an excellent target for treating Leishmaniasis.
    • Comment on this subject: 2 comments made

  • • 2+ votes

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  • Host–virus genome interactions: macro roles for microRNAs

    • Vinod Scaria, Manoj Hariharan, Beena Pillai, Souvik Maiti, Samir K. Brahmachari
      Original article citation: Cell Microbiol 9," 2784 - 2794, (2007).

    • Categories: Cell & Molecular Biology, Biotechnology, Clinical Medicine, and Genetics
    • Recommended by : Klein K on 02/08/2008 05:34AM GMT
      
      This is an interesting review describing the models of host-virus interactions mediated through microRNAs.
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  • Catechol-estrogen modified DNA: A better antigen for cancer autoantibody

    • W KHAN, K ALAM
      Original article citation: Archives of Biochemistry and Biophysics 465," 293 - 300, (2007).

    • Categories: Clinical Medicine and Cell & Molecular Biology
    • Recommended by : NAJMUL ISLAM on 02/05/2008 07:06AM GMT
      
      This paper helps in better understanding female sex hormone mediated DNA damage and its role in carcinogenesis as well as autoantibody formation against estrogen modified DNA.
    • Comment on this subject: 0 comments made