• Cancer stem cells

    • Self-Renewal of Murine Embryonic Stem Cells Is Supported by the Serine/Threonine Kinases Pim-1 and Pim-3

      • I. Aksoy, C. Sakabedoyan, P.-Y. Bourillot, A. B. Malashicheva, J. Mancip, K. Knoblauch, M. Afanassieff, P. Savatier,
      • Original article citation: Stem Cells 25," 2996 - 3004,
      • Categories: Cancer stem cells, Stem cell niches, Drug discovery, and Differentiation
      • Recommended by: Raja Radio on 12/27/2007 11:12PM GMT
      • Reasons for recommending:
        Seems like the paper is breaking the trends of serine/ threonine kinases, especially serine/ threonine kinases means it’s always meant only for aberrant expressions and or for cancer druggable targets. The French group has found that the proto-oncogene kinase pim-1 and pim-3 (in detail: Serine/Threonine Protein Kinases -> CAMK Group -> PIM Family -> Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 and Pim-3) plays important role in stem-cell renewal. Quite interesting paper, which igniting number of curiosities especially on the therapeutic side, extensively.

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