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Stem cell niches
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Centrosome misorientation reduces stem cell division during ageing
- Jun Cheng, Nezaket Türkel, Nahid Hemati, Margaret T. Fuller, Alan J. Hunt, Yukiko M. Yamashita,
- Original article citation: Nature doi:10.1038/nature07386 (2008)
- Categories: Stem cell niches, Tissue stem cells, Germ cells, and Regenerative medicine
- Recommended by: Shree Singh on 10/20/2008 08:10PM GMT
- Reasons for recommending:
A remarkable paper in the area of stem cell biology. It has been proposed that a decline in stem cell function contribute to tissue ageing. However, the underlying mechanism is poorly understood until this paper wherein for the first time authors identified a novel mechanistic link between the control of stem cell polarity and the age-related decline in tissue regenerative capacity.
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