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Nature Reports Stem Cells is no longer being updated. Although the journal club is no longer active, we hope that you will continue to enjoy the past content which is available here.

• Cancer stem cells

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  • A luminal epithelial stem cell that is a cell of origin for prostate cancer

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      Original article citation: Nature 461," 495 - 500, (2009).

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 10/01/2009 08:10PM GMT
      
      <p>Prostate tumours from a surprising source</p> <p>A luminal stem cell might fuel cancer</p> <p><a href="http://www.nature.com/stemcells/2009/0910/091001/full/stemcells.2009.127.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

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      Original article citation: Cell 138," 592 - 603, (2009).

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 08/13/2009 06:49PM GMT
      
      <p>Cancer stem cells resemble healthy stem cells</p> <p>Recent papers show how tumour-initiating cells work, and why they're hard to treat</p> <p><a href="http://www.nature.com/stemcells/2009/0908/090813/full/stemcells.2009.110.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

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      Original article citation: Proceedings of the National Academy of Sciences doi:10.1073/pnas.0905718106 (2009)

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 08/13/2009 06:49PM GMT
      
      <p>Cancer stem cells resemble healthy stem cells, resist chemotherapy</p> <p>Recent papers show how tumour-initiating cells work, and why they're hard to treat</p> <p><a href="http://www.nature.com/stemcells/2009/0908/090813/full/stemcells.2009.110.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

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      Original article citation: Cell Stem Cell 4," 226 - 235, (2009).

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 03/12/2009 08:17PM GMT
      
      <p>Treatment encourages more and more aggressive brain cancer stem cells</p> <p>Regulation is controlled by PTEN, PI3K/Akt and drug-effluxing ABCG2</p> <p><a href="http://www.nature.com/stemcells/2009/0903/090312/full/stemcells.2009.38.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • Association of reactive oxygen species levels and radioresistance in cancer stem cells

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      Original article citation: Nature doi:10.1038/nature07733 (2009)

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 02/05/2009 07:59PM GMT
      
      <p>How breast cancer resists treatment </p> <p>Healthy and cancerous stem cells protect their DNA</p> <p><a href="http://www.nature.com/stemcells/2009/0902/090205/full/stemcells.2009.21.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

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      Original article citation: Nature doi:10.1038/nature07589 (2008)

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 01/09/2009 07:11PM GMT
      
      <p>Tracking cancer to intestinal stem cells</p> <p>Two research teams follow cancer to its source</p> <p><a href="http://www.nature.com/stemcells/2009/0901/090108/full/stemcells.2008.162.html">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Crypt stem cells as the cells-of-origin of intestinal cancer

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      Original article citation: Nature doi:10.1038/nature07602 (2008)

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 01/09/2009 07:11PM GMT
      
      <p>Tracking cancer to intestinal stem cells</p> <p>Two research teams follow cancer to its source</p> <p><a href="http://www.nature.com/stemcells/2009/0901/090108/full/stemcells.2008.162.html">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

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      Original article citation: Nature 457," 51 - 56, (2009).

    • Categories: Cancer stem cells
    • Recommended by : Nicole DeGennaro on 01/09/2009 07:08PM GMT
      
      <p>Stalling cell division keeps leukaemia stem cells going</p> <p>The cell cycle inhibitor p21 gives cancer cells the chance to repair DNA</p> <p><a href="http://www.nature.com/stemcells/2009/0901/090108/full/stemcells.2009.13.html">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells

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      Original article citation: Cell 131," 1109 - 1123, (2007).

    • Categories: Cancer stem cells
    • Recommended by the Editor: Monya Baker on 01/09/2008 12:52AM GMT
      
      Please see Nature Reports Stem Cells highlight on this paper, MicroRNA reins in tumor-initiating cells, at http://www.nature.com/stemcells/2008/0801/080103/full/stemcells.2007.137.html
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  • Self-Renewal of Murine Embryonic Stem Cells Is Supported by the Serine/Threonine Kinases Pim-1 and Pim-3

    • I. Aksoy, C. Sakabedoyan, P.-Y. Bourillot, A. B. Malashicheva, J. Mancip, K. Knoblauch, M. Afanassieff, P. Savatier
      Original article citation: Stem Cells 25," 2996 - 3004,

    • Categories: Cancer stem cells, Stem cell niches, Drug discovery, and Differentiation
    • Recommended by : Raja Radio on 12/27/2007 11:12PM GMT
      
      Seems like the paper is breaking the trends of serine/ threonine kinases, especially serine/ threonine kinases means it’s always meant only for aberrant expressions and or for cancer druggable targets. The French group has found that the proto-oncogene kinase pim-1 and pim-3 (in detail: Serine/Threonine Protein Kinases -> CAMK Group -> PIM Family -> Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 and Pim-3) plays important role in stem-cell renewal. Quite interesting paper, which igniting number of curiosities especially on the therapeutic side, extensively.
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