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Nature Reports Stem Cells is no longer being updated. Although the journal club is no longer active, we hope that you will continue to enjoy the past content which is available here.

• Differentiation

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  • Stem cell fate dictated solely by altered nanotube dimension

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      Original article citation: Proceedings of the National Academy of Sciences doi:10.1073/pnas.0813200106 (2009)

    • Categories: Differentiation
    • Recommended by : Nicole DeGennaro on 02/05/2009 07:59PM GMT
      
      <p>Nanotubes guide mesenchymal stem cells toward becoming bone</p> <p>The surface a cell grows on can control its fate</p> <p><a href="http://www.nature.com/stemcells/2009/0902/090205/full/stemcells.2009.27.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

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      Original article citation: Cell Stem Cell 3," 519 - 532, (2008).

    • Categories: Differentiation
    • Recommended by : Nicole DeGennaro on 11/13/2008 09:46PM GMT
      
      <p>Human cortical neural cell balls</p> <p>Cells cultured in embryoid bodies self-organize into specific neural subtypes</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.147">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

    • M FULCO, Y CEN, P ZHAO, E HOFFMAN, M MCBURNEY, A SAUVE, V SARTORELLI
      Original article citation: Developmental Cell 14," 661 - 673, (2008).

    • Categories: Differentiation
    • Recommended by : Nicole DeGennaro on 05/23/2008 01:25PM GMT
      
      <p>Glucose restriction blocks skeletal muscle cell differentiation </p> <p>Aging pathways allow muscle progenitors to respond to nutrients </p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.87">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

    • Hannah H. Chang, Martin Hemberg, Mauricio Barahona, Donald E. Ingber, Sui Huang
      Original article citation: Nature 453," 544 - 547, (2008).

    • Categories: Differentiation
    • Recommended by : Nicole DeGennaro on 05/22/2008 03:30PM GMT
      
      <p>Chance and the single cell</p> <p>Fully multipotent cells fluctuate slowly between states with varying likelihoods of differentiation</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.72">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Genetic approaches identify adult pituitary stem cells

    • A. S. Gleiberman, T. Michurina, J. M. Encinas, J. L. Roig, P. Krasnov, F. Balordi, G. Fishell, M. G. Rosenfeld, G. Enikolopov
      Original article citation: Proceedings of the National Academy of Sciences 105," 6332 - 6337, (2008).

    • Categories: Differentiation
    • Recommended by : Nicole DeGennaro on 05/15/2008 03:25PM GMT
      
      <p>Pituitary stem cells found using a general stem cell marker</p> <p>Genetic approaches identify a distinct, postnatal stem cell population</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.77">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Marked differences in differentiation propensity among human embryonic stem cell lines

    • Kenji Osafune, Leslie Caron, Malgorzata Borowiak, Rita J Martinez, Claire S Fitz-Gerald, Yasunori Sato, Chad A Cowan, Kenneth R Chien, Douglas A Melton
      Original article citation: Nat Biotechnol doi:10.1038/nbt1383 (2008)

    • Categories: Differentiation
    • Recommended by the Editor: Monya Baker on 02/29/2008 12:56AM GMT
      
      <p> Underlying Differences <p> Various embryonic stem cell lines trend toward particular cell types <p>This article has been highlighted in <a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.41" ><i>Nature Reports Stem Cells.</i></a>
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  • Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells

    • Shinji Masui, Yuhki Nakatake, Yayoi Toyooka, Daisuke Shimosato, Rika Yagi, Kazue Takahashi, Hitoshi Okochi, Akihiko Okuda, Ryo Matoba, Alexei A. Sharov, Minoru S. H. Ko, Hitoshi Niwa
      Original article citation: Nat Cell Biol 9," 625 - 635, (2007).

    • Categories: Embryonic stem cells, Research tools, and Differentiation
    • Recommended by the Editor: Monya Baker on 01/12/2008 12:23AM GMT
      
      <p> Parsing pluripotency: the role of Sox2 <p> Parsing pluripotency: the role of Sox2 <p>This article has been selected for a <a href="http://www.nature.com/uidfinder/10.1038/ stemcells.2007.8 ">research highlight</a> on Nature Reports Stem Cells.
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  • Self-Renewal of Murine Embryonic Stem Cells Is Supported by the Serine/Threonine Kinases Pim-1 and Pim-3

    • I. Aksoy, C. Sakabedoyan, P.-Y. Bourillot, A. B. Malashicheva, J. Mancip, K. Knoblauch, M. Afanassieff, P. Savatier
      Original article citation: Stem Cells 25," 2996 - 3004,

    • Categories: Cancer stem cells, Stem cell niches, Drug discovery, and Differentiation
    • Recommended by : Raja Radio on 12/27/2007 11:12PM GMT
      
      Seems like the paper is breaking the trends of serine/ threonine kinases, especially serine/ threonine kinases means it’s always meant only for aberrant expressions and or for cancer druggable targets. The French group has found that the proto-oncogene kinase pim-1 and pim-3 (in detail: Serine/Threonine Protein Kinases -> CAMK Group -> PIM Family -> Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 and Pim-3) plays important role in stem-cell renewal. Quite interesting paper, which igniting number of curiosities especially on the therapeutic side, extensively.
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  • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

    • Tarjei S. Mikkelsen, Manching Ku, David B. Jaffe, Biju Issac, Erez Lieberman, Georgia Giannoukos, Pablo Alvarez, William Brockman, Tae-Kyung Kim, Richard P. Koche, William Lee, Eric Mendenhall, Aisling O’Donovan, Aviva Presser, Carsten Russ, Xiaohui Xie, Alexander Meissner, Marius Wernig, Rudolf Jaenisch, Chad Nusbaum, Eric S. Lander, Bradley E. Bernstein
      Original article citation: Nature 448," (2007).

    • Categories: Differentiation and Research tools
    • Recommended by : Natalie DeWitt on 08/14/2007 05:41PM GMT
      
      This paper presents a technique for preparing genome wide chromatin state maps for cells in different states of differentiation and pluripotency. They find lysine trimethylation signatures that can discriminate between genes that are expressed, posed for expression, or repressed.
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  • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

    • T. Kunath, M. K. Saba-El-Leil, M. Almousailleakh, J. Wray, S. Meloche, A. Smith
      Original article citation: Development 134,"

    • Categories: Embryonic stem cells and Differentiation
    • Recommended by : Sally Lowell on 08/07/2007 02:34PM GMT
      
      This paper describes an important advance in our understanding of how embryonic stem cells make the transition from pluripotency to lineage commitment. FGF/Erk signalling was already known to be required for nerual specification but this work reveals that it is also required for specification into other lineages, including mesoderm.
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