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Nature Reports Stem Cells is no longer being updated. Although the journal club is no longer active, we hope that you will continue to enjoy the past content which is available here.

• Drug discovery

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  • Virus-free induction of pluripotency and subsequent excision of reprogramming factors

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      Original article citation: Nature doi:10.1038/nature07864 (2009)

    • Categories: Drug discovery
    • Recommended by : Nicole DeGennaro on 04/03/2009 02:29PM GMT
      
      <p>iPS cell technology gains momentum in drug discovery</p> <p>iPS cells made without viral vectors may help develop drugs</p> <p><a href="http://www.nature.com/nrd/journal/v8/n4/full/nrd2867.html">See our summary on <i>Nature Reviews Drug Discovery<i></a></p>
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  • piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

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      Original article citation: Nature doi:10.1038/nature07863 (2009)

    • Categories: Drug discovery
    • Recommended by : Nicole DeGennaro on 04/03/2009 02:28PM GMT
      
      p>iPS cell technology gains momentum in drug discovery</p> <p>iPS cells made without viral vectors may help develop drugs</p> <p><a href="http://www.nature.com/nrd/journal/v8/n4/full/nrd2867.html">See our summary on <i>Nature Reviews Drug Discovery<i></a></p>
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  • Self-Renewal of Murine Embryonic Stem Cells Is Supported by the Serine/Threonine Kinases Pim-1 and Pim-3

    • I. Aksoy, C. Sakabedoyan, P.-Y. Bourillot, A. B. Malashicheva, J. Mancip, K. Knoblauch, M. Afanassieff, P. Savatier
      Original article citation: Stem Cells 25," 2996 - 3004,

    • Categories: Cancer stem cells, Stem cell niches, Drug discovery, and Differentiation
    • Recommended by : Raja Radio on 12/27/2007 11:12PM GMT
      
      Seems like the paper is breaking the trends of serine/ threonine kinases, especially serine/ threonine kinases means it’s always meant only for aberrant expressions and or for cancer druggable targets. The French group has found that the proto-oncogene kinase pim-1 and pim-3 (in detail: Serine/Threonine Protein Kinases -> CAMK Group -> PIM Family -> Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 and Pim-3) plays important role in stem-cell renewal. Quite interesting paper, which igniting number of curiosities especially on the therapeutic side, extensively.
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  • Elements of a Neural Stem Cell Niche Derived from Embryonic Stem Cells

    • Chris Pierret, Kathleen Spears, Jason A. Morrison, Joel A. Maruniak, Martin L. Katz, Mark D. Kirk
      Original article citation: Stem Cells and Development 16," 1017 - 1026, (2007).

    • Categories: Stem cell niches, Tissue stem cells, Drug discovery, and Research tools
    • Recommended by : Raja Radio on 12/27/2007 11:06PM GMT
      
      The authors have developed an exogenous mitogenic growth factors free,novel stem-cells based method to study of neurogenesis process, stem cell properties and their behaviours in a neural stem cell (NSC) niches,in addition to possibility to study the role of stem-cell niches in normal and pathological conditions, etc. Apart from further possibilities of applications in stem cell transplantation, moreover, on the other hand, the basic idea/concepts behind the method are also creating number of curiosity questions such as - whether it is possible to expand into other stem-cells niches such as osteoblasic niche, pre-metastatic niche as well as microenvironment study in model organisms?, etc., etc. A remarkable paper in the area of methods development.
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  • Enhanced Unique Pattern of Hematopoietic Cell Mobilization Induced by the CXCR4 Antagonist 4F-benzoyl-TN14003

    • M. Abraham, K. Biyder, M. Begin, H. Wald, I. D. Weiss, E. Galun, A. Nagler, A. Peled
      Original article citation: Stem Cells doi:10.1634/stemcells.2007-0161 (2007)

    • Categories: Hematopoietic stem cells, Stem cell niches, and Drug discovery
    • Recommended by : Natalie DeWitt on 06/06/2007 09:58PM GMT
      
      10.1634/stemcells.2007-0161
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