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Nature Reports Stem Cells is no longer being updated. Although the journal club is no longer active, we hope that you will continue to enjoy the past content which is available here.

• Embryonic stem cells

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  • Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell Signature Dominated by a Single Seed Sequence

    • L. C Laurent, J. Chen, I. Ulitsky, F. J. Mueller, C. Lu, R. Shamir, J. B. Fan, J. F Loring
      Original article citation: Stem Cells doi:10.1634/stemcells.2007-1081 (2008)

    • Categories: Embryonic stem cells
    • Recommended by : rizwan romee on 05/09/2008 11:23PM GMT
      
      This study highlights the importance of microRNAs in regulating the differentiation and in maintaining the "stemness" of human embryonic stem cells.
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  • Copy Number Variant Analysis of Human Embryonic Stem Cells

    • H. Wu, K. J. Kim, K. Mehta, S. Paxia, A. Sundstrom, T. Anantharaman, A. I. Kuraishy, T. Doan, J. Ghosh, A. D. Pyle, A. Clark, W. Lowry, G. Fan, T. Baxter, B. Mishra, Y. Sun, M. A. Teitell
      Original article citation: Stem Cells doi:10.1634/stemcells.2007-0993 (2008)

    • Categories: Embryonic stem cells
    • Recommended by the Editor: Monya Baker on 04/09/2008 12:10AM GMT
      
      <p>See our summary on <i>Nature Reports Stem Cells</i></a> <h2><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.62"> Some human embryonic stem cells have more gene copies than others <p> Researchers should consider a new layer of genetic variability
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  • Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells

    • Shinji Masui, Yuhki Nakatake, Yayoi Toyooka, Daisuke Shimosato, Rika Yagi, Kazue Takahashi, Hitoshi Okochi, Akihiko Okuda, Ryo Matoba, Alexei A. Sharov, Minoru S. H. Ko, Hitoshi Niwa
      Original article citation: Nat Cell Biol 9," 625 - 635, (2007).

    • Categories: Embryonic stem cells, Research tools, and Differentiation
    • Recommended by the Editor: Monya Baker on 01/12/2008 12:23AM GMT
      
      <p> Parsing pluripotency: the role of Sox2 <p> Parsing pluripotency: the role of Sox2 <p>This article has been selected for a <a href="http://www.nature.com/uidfinder/10.1038/ stemcells.2007.8 ">research highlight</a> on Nature Reports Stem Cells.
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  • Patient-Specific Stem Cell Lines Derived from Human Parthenogenetic Blastocysts

    • E.S. Revazova, N.A. Turovets, O.D. Kochetkova, L.B. Kindarova, L.N. Kuzmichev, J.D. Janus, M.V. Pryzhkova
      Original article citation: Cloning and Stem Cells doi:10.1089/clo.2007.0033 (2007)

    • Categories: Embryonic stem cells, Regenerative medicine, and Early embryogenesis
    • Recommended by : Natalie DeWitt on 08/14/2007 05:37PM GMT
      
      The paper presents a new method for obtaining embryonic stem cells. Instead of using blastocysts from in vitro fertilization, they artificially stimulate oocytes to begin cleavage to form a parthenote (in this case, an embryo initiated without sperm). They derive the embryonic stem cells from the inner cell mass. This technique would allow patient-derived stem cells to be derived for egg donors. Parthenogenic human embryos do not develop to term so this method might be less ethically objectionable to some as it doesn't destroy an embryo capable of forming an individual person.
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  • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

    • T. Kunath, M. K. Saba-El-Leil, M. Almousailleakh, J. Wray, S. Meloche, A. Smith
      Original article citation: Development 134,"

    • Categories: Embryonic stem cells and Differentiation
    • Recommended by : Sally Lowell on 08/07/2007 02:34PM GMT
      
      This paper describes an important advance in our understanding of how embryonic stem cells make the transition from pluripotency to lineage commitment. FGF/Erk signalling was already known to be required for nerual specification but this work reveals that it is also required for specification into other lineages, including mesoderm.
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  • A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

    • M GUENTHER, S LEVINE, L BOYER, R JAENISCH, R YOUNG
      Original article citation: Cell 130," (2007).

    • Categories: Embryonic stem cells and Differentiation
    • Recommended by : Natalie DeWitt on 07/18/2007 09:43PM GMT
      
      Surprisingly, events after transcriptional initiation may play a larger role in regulating gene expression than previously thought, this study shows.
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  • The Wwp2-mediated Ubiquitination of the RNA Polymerase II Large Subunit in Mouse Embryonic Pluripotent Stem Cells

    • H. Li, Z. Zhang, B. Wang, J. Zhang, Y. Zhao, Y. Jin
      Original article citation: Molecular and Cellular Biology doi:10.1128/MCB.01667-06 (2007)

    • Categories: Embryonic stem cells
    • Recommended by : Natalie DeWitt on 06/06/2007 09:38PM GMT
      
      10.1128/MCB.01667-06
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  • Tissue Engineering with Chondrogenically-differentiated Human Embryonic Stem Cells

    • E. J. Koay, G. M.B. Hoben, K. A. Athanasiou
      Original article citation: Stem Cells doi:10.1634/stemcells.2007-0105 (2007)

    • Categories: Embryonic stem cells, Regenerative medicine, and Differentiation
    • Recommended by : Natalie DeWitt on 06/06/2007 09:37PM GMT
      
      10.1634/stemcells.2007-0105
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  • Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines

    • B DOBLE, S PATEL, G WOOD, L KOCKERITZ, J WOODGETT
      Original article citation: Developmental Cell 12," (2007).

    • Categories: Embryonic stem cells
    • Recommended by : Natalie DeWitt on 06/06/2007 09:37PM GMT
      
      10.1016/j.devcel.2007.04.001
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  • Regulated Nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells

    • M. Takenaga, M. Fukumoto, Y. Hori
      Original article citation: Journal of Cell Science 120,"

    • Categories: Embryonic stem cells and Differentiation
    • Recommended by : Natalie DeWitt on 06/06/2007 09:36PM GMT
      
      10.1242/jcs.004127
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