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Nature Reports Stem Cells is no longer being updated. Although the journal club is no longer active, we hope that you will continue to enjoy the past content which is available here.

• Regenerative medicine

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  • Therapeutic cloning in individual parkinsonian mice

    • Viviane Tabar, Mark Tomishima, Georgia Panagiotakos, Sayaka Wakayama, Jayanthi Menon, Bill Chan, Eiji Mizutani, George Al-Shamy, Hiroshi Ohta, Teruhiko Wakayama, Lorenz Studer
      Original article citation: Nat Med 14," 379 - 381, (2008).

    • Categories: Regenerative medicine
    • Recommended by : Nicole DeGennaro on 06/05/2008 08:37PM GMT
      
      <p>Self or not for Parkinson's</p> <p>Evidence that genetically matched neurons make better transplants may not hold true for humans</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.90">See our summary on <i>Nature Reports Stem Cells</i></a></p> <p>Questioning the self cell</p> <p>A surprising study indicates that non-self mesenchymal stem cells might be just as therapeutic as one's own stem cells</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.86">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • A chemical approach to stem-cell biology and regenerative medicine

    • Yue Xu, Yan Shi, Sheng Ding
      Original article citation: Nature 453," 338 - 344, (2008).

    • Categories: Regenerative medicine
    • Recommended by : Nicole DeGennaro on 05/15/2008 07:38PM GMT
      
      <p>Sheng Ding: small molecules for stem cells</p> <p>Sheng Ding describes how to take a chemical approach to regenerative medicine</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.75">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Tolerance strategies for stem-cell-based therapies

    • Ann P. Chidgey, Daniel Layton, Alan Trounson, Richard L. Boyd
      Original article citation: Nature 453," 330 - 337, (2008).

    • Categories: Regenerative medicine
    • Recommended by : Nicole DeGennaro on 05/15/2008 07:35PM GMT
      
      <p>Richard Boyd and Ann Chidgey: protecting cells from immune attack</p> <p>Inducing tolerance to transplanted cells could make stem-cell therapy more enduring and versatile</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.79">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Regenerative medicine and human models of human disease

    • Kenneth R. Chien
      Original article citation: Nature 453," 302 - 305, (2008).

    • Categories: Regenerative medicine
    • Recommended by : Nicole DeGennaro on 05/15/2008 07:32PM GMT
      
      <p>Ken Chien: the road ahead for regenerative medicine</p> <p>Human models of human disease are likely to be the first benefits of stem cells to medicine</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.80">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Stem-cell-based therapy and lessons from the heart

    • Robert Passier, Linda W. van Laake, Christine L. Mummery
      Original article citation: Nature 453," 322 - 329, (2008).

    • Categories: Regenerative medicine
    • Recommended by : Nicole DeGennaro on 05/15/2008 03:38PM GMT
      
      <p>Christine Mummery: regenerating the heart</p> <p>Scientists search for the best ways to make therapies embryonic stem cells and adult tissues</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.76">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division

    • Y. M. Yamashita, A. P. Mahowald, J. R. Perlin, M. T. Fuller
      Original article citation: Science 315," 518 - 521, (2007).

    • Categories: Tissue stem cells, Stem cell niches, Germ cells, and Regenerative medicine
    • Recommended by : Shree Singh on 05/01/2008 02:48AM GMT
      
      This is a seminal article in the stem cell field wherein for the first time the authors demonstrated that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions. Specifically, the mother centrosome is always inherited by the stem cell, whereas the daughter centrosome is inherited by the differentiating cell.
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  • Restoration of Human Dystrophin Following Transplantation of Exon-Skipping-Engineered DMD Patient Stem Cells into Dystrophic Mice

    • R BENCHAOUIR
      Original article citation: Cell Stem Cell 1," 646 - 657, (2007).

    • Categories: Regenerative medicine
    • Recommended by the Editor: Monya Baker on 01/11/2008 11:41PM GMT
      
      This was selected for <a href=" http://www.nature.com/stemcells/2008/0801/080110/full/stemcells.2007.141.html " > a research highlight </a> for Nature Reports Stem Cells.
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  • Patient-Specific Stem Cell Lines Derived from Human Parthenogenetic Blastocysts

    • E.S. Revazova, N.A. Turovets, O.D. Kochetkova, L.B. Kindarova, L.N. Kuzmichev, J.D. Janus, M.V. Pryzhkova
      Original article citation: Cloning and Stem Cells doi:10.1089/clo.2007.0033 (2007)

    • Categories: Embryonic stem cells, Regenerative medicine, and Early embryogenesis
    • Recommended by : Natalie DeWitt on 08/14/2007 05:37PM GMT
      
      The paper presents a new method for obtaining embryonic stem cells. Instead of using blastocysts from in vitro fertilization, they artificially stimulate oocytes to begin cleavage to form a parthenote (in this case, an embryo initiated without sperm). They derive the embryonic stem cells from the inner cell mass. This technique would allow patient-derived stem cells to be derived for egg donors. Parthenogenic human embryos do not develop to term so this method might be less ethically objectionable to some as it doesn't destroy an embryo capable of forming an individual person.
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  • p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

    • Makoto Senoo Frank McKeon
      Original article citation: Cell 129," 523 - 536, (2007).

    • Categories: Tissue stem cells, Reprogramming, Regenerative medicine, and Cancer stem cells
    • Recommended by : Hussain Abidi on 06/10/2007 10:42PM GMT
      
      This paper showed how absence p63 can contribute to exhaustion of adult epithelial stem cells. Since 80% of all known cancers are of epithelial in origin this study is important in deciphering the mechanisms by which stem cell survivial factors are regulated in cacner cells.
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  • Differentiation in vivo of Cardiac Committed Human Embryonic Stem Cells in Post-myocardial Infarcted Rats

    • A. Tomescot, J. Leschik, V. Bellamy, G. Dubois, E. Messas, P. Bruneval, M. Desnos, A. A. Hagege, M. Amit, J. Itskovitz, P. Menasche, M. Puceat
      Original article citation: Stem Cells doi:10.1634/stemcells.2007-0133 (2007)

    • Categories: Regenerative medicine, Tissue stem cells, and Differentiation
    • Recommended by : Natalie DeWitt on 06/06/2007 09:37PM GMT
      
      10.1634/stemcells.2007-0133
    • Comment on this subject: 1 comment made