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Nature Reports Stem Cells is no longer being updated. Although the journal club is no longer active, we hope that you will continue to enjoy the past content which is available here.

• Stem cell niches

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  • Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements

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      Original article citation: Nature doi:10.1038/nature08209 (2009)

    • Categories: Stem cell niches
    • Recommended by : Nicole DeGennaro on 07/09/2009 05:57PM GMT
      
      <p>A satellite cell surprise</p> <p>Muscle stem cells have unexpected age-dependent genetic requirements</p> <p><a href="http://www.nature.com/stemcells/2009/0907/090709/full/stemcells.2009.95.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila

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      Original article citation: Nat Cell Biol doi:10.1038/ncb1874 (2009)

    • Categories: Stem cell niches
    • Recommended by : Nicole DeGennaro on 05/28/2009 06:02PM GMT
      
      <p>A wicked gene shrinks numbers of germline stem cells</p> <p>Ribosome biogenesis regulates asymmetric growth and self-renewal of these cells in <i>Drosophila</i></p> <p><a href="http://www.nature.com/stemcells/2009/0905/090528/full/stemcells.2009.77.html">See our summary on <i>Nature Reports Stem Cells<i></a></p>
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  • Centrosome misorientation reduces stem cell division during ageing

    • Jun Cheng, Nezaket Türkel, Nahid Hemati, Margaret T. Fuller, Alan J. Hunt, Yukiko M. Yamashita
      Original article citation: Nature doi:10.1038/nature07386 (2008)

    • Categories: Stem cell niches, Tissue stem cells, Germ cells, and Regenerative medicine
    • Recommended by : Shree Singh on 10/20/2008 08:10PM GMT
      
      A remarkable paper in the area of stem cell biology. It has been proposed that a decline in stem cell function contribute to tissue ageing. However, the underlying mechanism is poorly understood until this paper wherein for the first time authors identified a novel mechanistic link between the control of stem cell polarity and the age-related decline in tissue regenerative capacity.
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  • Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary

    • A. M. O'Reilly, H.-H. Lee, M. A. Simon
      Original article citation: The Journal of Cell Biology 182," 801 - 815, (2008).

    • Categories: Stem cell niches
    • Recommended by : Nicole DeGennaro on 08/28/2008 06:02PM GMT
      
      p>A niche with no cells</p> <p>Integrins play a vital role in the positioning of follicle stem cells in the <i>Drosophila</i> ovary</p> <p><a href="http://www.nature.com/uidfinder/10.1038/stemcells.2008.122">See our summary on <i>Nature Reports Stem Cells</i></a></p>
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  • Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division

    • Y. M. Yamashita, A. P. Mahowald, J. R. Perlin, M. T. Fuller
      Original article citation: Science 315," 518 - 521, (2007).

    • Categories: Tissue stem cells, Stem cell niches, Germ cells, and Regenerative medicine
    • Recommended by : Shree Singh on 05/01/2008 02:48AM GMT
      
      This is a seminal article in the stem cell field wherein for the first time the authors demonstrated that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions. Specifically, the mother centrosome is always inherited by the stem cell, whereas the daughter centrosome is inherited by the differentiating cell.
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  • Self-Renewal of Murine Embryonic Stem Cells Is Supported by the Serine/Threonine Kinases Pim-1 and Pim-3

    • I. Aksoy, C. Sakabedoyan, P.-Y. Bourillot, A. B. Malashicheva, J. Mancip, K. Knoblauch, M. Afanassieff, P. Savatier
      Original article citation: Stem Cells 25," 2996 - 3004,

    • Categories: Cancer stem cells, Stem cell niches, Drug discovery, and Differentiation
    • Recommended by : Raja Radio on 12/27/2007 11:12PM GMT
      
      Seems like the paper is breaking the trends of serine/ threonine kinases, especially serine/ threonine kinases means it’s always meant only for aberrant expressions and or for cancer druggable targets. The French group has found that the proto-oncogene kinase pim-1 and pim-3 (in detail: Serine/Threonine Protein Kinases -> CAMK Group -> PIM Family -> Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 and Pim-3) plays important role in stem-cell renewal. Quite interesting paper, which igniting number of curiosities especially on the therapeutic side, extensively.
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  • Elements of a Neural Stem Cell Niche Derived from Embryonic Stem Cells

    • Chris Pierret, Kathleen Spears, Jason A. Morrison, Joel A. Maruniak, Martin L. Katz, Mark D. Kirk
      Original article citation: Stem Cells and Development 16," 1017 - 1026, (2007).

    • Categories: Stem cell niches, Tissue stem cells, Drug discovery, and Research tools
    • Recommended by : Raja Radio on 12/27/2007 11:06PM GMT
      
      The authors have developed an exogenous mitogenic growth factors free,novel stem-cells based method to study of neurogenesis process, stem cell properties and their behaviours in a neural stem cell (NSC) niches,in addition to possibility to study the role of stem-cell niches in normal and pathological conditions, etc. Apart from further possibilities of applications in stem cell transplantation, moreover, on the other hand, the basic idea/concepts behind the method are also creating number of curiosity questions such as - whether it is possible to expand into other stem-cells niches such as osteoblasic niche, pre-metastatic niche as well as microenvironment study in model organisms?, etc., etc. A remarkable paper in the area of methods development.
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  • Enhanced Unique Pattern of Hematopoietic Cell Mobilization Induced by the CXCR4 Antagonist 4F-benzoyl-TN14003

    • M. Abraham, K. Biyder, M. Begin, H. Wald, I. D. Weiss, E. Galun, A. Nagler, A. Peled
      Original article citation: Stem Cells doi:10.1634/stemcells.2007-0161 (2007)

    • Categories: Hematopoietic stem cells, Stem cell niches, and Drug discovery
    • Recommended by : Natalie DeWitt on 06/06/2007 09:58PM GMT
      
      10.1634/stemcells.2007-0161
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  • Atrial-Radiofrequency Catheter Ablation Mediated Targeting of Mesenchymal Stromal Cells

    • P. A. Schweizer, U. Krause, R. Becker, A. Seckinger, A. Bauer, C. Hardt, V. Eckstein, A. D. Ho, M. Koenen, H. A. Katus, J. Zehelein
      Original article citation: Stem Cells 25," (2007).

    • Categories: Regenerative medicine, Mesenchymal stem cells, and Stem cell niches
    • Recommended by : Natalie DeWitt on 06/06/2007 09:35PM GMT
      
      10.1634/stemcells.2006-0682
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