Recent paper recommendations for Nature Reports: Stemcells The latest recommended papers from Nature Reports: Stemcells http://spotlight.nature.com/stemcells/papers en-us 40 Packaging DNA for pluripotency Packaging DNA for pluripotency

An RNA interference screen reveals a surprising player

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]]> Thu, 24 Jul 2008 18:46:19 -0000 http://spotlight.nature.com/stemcells/paper/417 http://spotlight.nature.com/stemcells/paper/417 Nicole DeGennaro The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling Villi-nous fly guts

Stem cells in the fly hindgut mirror the niche in mammalian villi

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]]> Thu, 24 Jul 2008 18:45:30 -0000 http://spotlight.nature.com/stemcells/paper/416 http://spotlight.nature.com/stemcells/paper/416 Nicole DeGennaro Mouse embryonic stem cell–based functional assay to evaluate mutations in BRCA2 Embryoic stem cells answer questions about breast cancer

A cell-based assay identifies deleterious mutations in BRCA2

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]]> Thu, 10 Jul 2008 15:17:59 -0000 http://spotlight.nature.com/stemcells/paper/415 http://spotlight.nature.com/stemcells/paper/415 Nicole DeGennaro Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches Growing blood in a dish

Researchers develop new models for generating functional haematopoietic stem cells ex vivo

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]]> Thu, 10 Jul 2008 15:17:16 -0000 http://spotlight.nature.com/stemcells/paper/414 http://spotlight.nature.com/stemcells/paper/414 Nicole DeGennaro Extensive Hematopoietic Stem Cell Generation in the AGM Region via Maturation of VE-Cadherin+CD45+ Pre-Definitive HSCs Growing blood in a dish

Researchers develop new models for generating functional haematopoietic stem cells ex vivo

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]]> Thu, 10 Jul 2008 15:16:37 -0000 http://spotlight.nature.com/stemcells/paper/413 http://spotlight.nature.com/stemcells/paper/413 Nicole DeGennaro Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells A metasignalling network makes mucles age

Regeneration is actively repressed in a metasignalling network

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]]> Thu, 19 Jun 2008 15:56:54 -0000 http://spotlight.nature.com/stemcells/paper/409 http://spotlight.nature.com/stemcells/paper/409 Nicole DeGennaro Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells Transcription factors cluster together

An analysis that reveals these clusters also helps clarify cooperative binding

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]]> Thu, 19 Jun 2008 15:56:25 -0000 http://spotlight.nature.com/stemcells/paper/408 http://spotlight.nature.com/stemcells/paper/408 Nicole DeGennaro Dissecting direct reprogramming through integrative genomic analysis Unlocking reprogramming

New strategy could lead to changes in the quality, quantity of induced pluripotent cells

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]]> Thu, 12 Jun 2008 20:14:42 -0000 http://spotlight.nature.com/stemcells/paper/405 http://spotlight.nature.com/stemcells/paper/405 Nicole DeGennaro Wound repair and regeneration Geoff Gurtner: learning healing from scars

For its power to be harnessed, wound repair must reveal its molecular secrets

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]]> Thu, 12 Jun 2008 20:14:16 -0000 http://spotlight.nature.com/stemcells/paper/404 http://spotlight.nature.com/stemcells/paper/404 Nicole DeGennaro Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts Unlocking reprogramming

New strategy could lead to changes in the quality, quantity of induced pluripotent cells

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]]> Thu, 12 Jun 2008 20:12:55 -0000 http://spotlight.nature.com/stemcells/paper/403 http://spotlight.nature.com/stemcells/paper/403 Nicole DeGennaro Neonatal Chimerization with Human Glial Progenitor Cells Can Both Remyelinate and Rescue the Otherwise Lethally Hypomyelinated Shiverer Mouse Human cell transplants stop the shivers

Injected human glial progenitor cells grow into functional myelin sheaths in shiverer mice

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]]> Thu, 12 Jun 2008 20:11:32 -0000 http://spotlight.nature.com/stemcells/paper/402 http://spotlight.nature.com/stemcells/paper/402 Nicole DeGennaro An international gap in human ES cell research Stem cell research: more support brings more papers

Publication rates in human embryonic stem cell research reflect government policies

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]]> Thu, 12 Jun 2008 20:11:08 -0000 http://spotlight.nature.com/stemcells/paper/401 http://spotlight.nature.com/stemcells/paper/401 Nicole DeGennaro Identifying Under- and Overperforming Countries in Research Related to Human Embryonic Stem Cells Stem cell research: more support brings more papers

Publication rates in human embryonic stem cell research reflect government policies

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]]> Thu, 12 Jun 2008 20:10:44 -0000 http://spotlight.nature.com/stemcells/paper/400 http://spotlight.nature.com/stemcells/paper/400 Nicole DeGennaro Immunostimulatory Effects of Mesenchymal Stem Cell-Derived Neurons: Implications for Stem Cell Therapy in Allogeneic Transplantations Questioning the self cell

A surprising study indicates that non-self mesenchymal stem cells might be just as therapeutic as one's own stem cells

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]]> Thu, 05 Jun 2008 20:40:20 -0000 http://spotlight.nature.com/stemcells/paper/398 http://spotlight.nature.com/stemcells/paper/398 Nicole DeGennaro Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study Questioning the self cell

A surprising study indicates that non-self mesenchymal stem cells might be just as therapeutic as one's own stem cells

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]]> Thu, 05 Jun 2008 20:39:44 -0000 http://spotlight.nature.com/stemcells/paper/397 http://spotlight.nature.com/stemcells/paper/397 Nicole DeGennaro Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal Leonard Zon: unlocking stemness in haematopoiesis

After decades of study, blood still holds secrets and lessons of self-renewal

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]]> Thu, 05 Jun 2008 20:38:20 -0000 http://spotlight.nature.com/stemcells/paper/396 http://spotlight.nature.com/stemcells/paper/396 Nicole DeGennaro Therapeutic cloning in individual parkinsonian mice Self or not for Parkinson's

Evidence that genetically matched neurons make better transplants may not hold true for humans

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Questioning the self cell

A surprising study indicates that non-self mesenchymal stem cells might be just as therapeutic as one's own stem cells

See our summary on Nature Reports Stem Cells

]]> Thu, 05 Jun 2008 20:37:52 -0000 http://spotlight.nature.com/stemcells/paper/395 http://spotlight.nature.com/stemcells/paper/395 Nicole DeGennaro PML targeting eradicates quiescent leukaemia-initiating cells Leukaemia: A provoking end?

There is good evidence that leukaemia-initiating cells (LICs) are responsible for tumour initiation and maintenance, and probably for relapse and resistance to therapy.

See our summary on Nature Reviews Cancer

]]> Thu, 29 May 2008 13:35:05 -0000 http://spotlight.nature.com/stemcells/paper/392 http://spotlight.nature.com/stemcells/paper/392 Nicole DeGennaro Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt Glucose restriction blocks skeletal muscle cell differentiation

Aging pathways allow muscle progenitors to respond to nutrients

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]]> Fri, 23 May 2008 13:25:43 -0000 http://spotlight.nature.com/stemcells/paper/390 http://spotlight.nature.com/stemcells/paper/390 Nicole DeGennaro Transcriptome-wide noise controls lineage choice in mammalian progenitor cells Chance and the single cell

Fully multipotent cells fluctuate slowly between states with varying likelihoods of differentiation

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]]> Thu, 22 May 2008 15:30:22 -0000 http://spotlight.nature.com/stemcells/paper/389 http://spotlight.nature.com/stemcells/paper/389 Nicole DeGennaro The ground state of embryonic stem cell self-renewal Off with differentiation

Embryonic stem cells can be grown without the complex biological ingredients that normally activate self-renewal

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]]> Thu, 22 May 2008 15:28:54 -0000 http://spotlight.nature.com/stemcells/paper/388 http://spotlight.nature.com/stemcells/paper/388 Nicole DeGennaro A chemical approach to stem-cell biology and regenerative medicine Sheng Ding: small molecules for stem cells

Sheng Ding describes how to take a chemical approach to regenerative medicine

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]]> Thu, 15 May 2008 19:38:34 -0000 http://spotlight.nature.com/stemcells/paper/387 http://spotlight.nature.com/stemcells/paper/387 Nicole DeGennaro Imaging stem-cell-driven regeneration in mammals Timm Schroeder: stem cell tracking

Visualization techniques are improving, but stem cells are still tough to watch

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]]> Thu, 15 May 2008 19:36:59 -0000 http://spotlight.nature.com/stemcells/paper/386 http://spotlight.nature.com/stemcells/paper/386 Nicole DeGennaro Tolerance strategies for stem-cell-based therapies Richard Boyd and Ann Chidgey: protecting cells from immune attack

Inducing tolerance to transplanted cells could make stem-cell therapy more enduring and versatile

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]]> Thu, 15 May 2008 19:35:30 -0000 http://spotlight.nature.com/stemcells/paper/385 http://spotlight.nature.com/stemcells/paper/385 Nicole DeGennaro Regenerative medicine and human models of human disease Ken Chien: the road ahead for regenerative medicine

Human models of human disease are likely to be the first benefits of stem cells to medicine

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]]> Thu, 15 May 2008 19:32:48 -0000 http://spotlight.nature.com/stemcells/paper/384 http://spotlight.nature.com/stemcells/paper/384 Nicole DeGennaro